Development of stabilized environmentally sensitive polymeric nanoparticles

稳定环境敏感聚合物纳米粒子的开发

• 批准号: RGPIN-2015-05891
• 负责人: Xing, Malcolm
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590701
• 关键词: Development; stabilized; environmentally; sensitive; polymeric

Research Problem: Nanoparticles have been widely studied as carriers to deliver hydrophobic molecules to targeted locations. Hydrophobic molecules do not disperse easily in water and can aggregate, thereby compromising their efficacy. Nanoparticles overcome this challenge by offering a hydrophobic core for hydrophobic payloads, while providing a hydrophilic shell that promotes free dispersion in aqueous solution. Nanoparticles offer the additional benefit to improve payload stability by encapsulating cargos to avoid adverse contact with destabilizing agents before their destination. Recently, progress has been made in developing environmentally sensitive nanoparticles that release their payloads in response to environmental stimuli, which can be either chemical (pH, redox) or physical (temperature, light). Improving the stability and loading efficiency of nanoparticles is a key consideration for a variety of applications.

研究问题：纳米颗粒作为载体被广泛研究，以将疏水分子传递到目标位置。疏水性分子不容易分散在水中，并且可以聚集，从而损害其功效。纳米颗粒通过为疏水有效载荷提供疏水核，同时提供促进在水溶液中自由分散的亲水壳来克服这一挑战。纳米颗粒提供了额外的好处，通过封装货物，以避免在其目的地之前与不稳定剂的不利接触，提高有效载荷的稳定性。最近，在开发环境敏感的纳米颗粒方面取得了进展，这些纳米颗粒响应于环境刺激而释放其有效载荷，这些环境刺激可以是化学的（pH、氧化还原）或物理的（温度、光）。 提高纳米颗粒的稳定性和负载效率是各种应用的关键考虑因素。