Probing Bone Morphogenetic Protein function in Cranial Neural Crest cells.

探索颅神经嵴细胞中的骨形态发生蛋白功能。

• 批准号: RGPIN-2015-06006
• 负责人: Graf, Daniel
• 金额: $ 2.48万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590776
• 关键词: Probing; Bone; Morphogenetic; Protein; function

The orofacial region is most complex. It comes in a wide variety of shapes and is home to several highly specialized structures. Central to its development are cranial neural crest cells (CNC). During embryonic development CNC cells migrate from the neural plate border to the branchial arches from which the facial prominences and different tissues are formed. CNC cells are multipotent stem cells that give rise to bone, cartilage, nerves, teeth, glial cells, melanocytes, and connective tissue of the face. The signals controlling their migration, differentiation, and proliferation are still only partly understood, though the importance of only a handful of extracellular signalling networks, such as Sonic hedgehog (Shh), Bone Morphogenetic Protein (Bmp), Fibroblast Growth Factor (Fgf), and Wnt/ß-catenin signalling, is well established. These pathways are used in a reiterated fashion during development, and thus place, time, and duration of their signalling activity are all important.

口面部区域是最复杂的。它有各种各样的形状，是几个高度专业化的结构的所在地。其发育的中心是颅神经嵴细胞（CNC）。在胚胎发育过程中，CNC细胞从神经板边缘迁移到鳃弓，从鳃弓形成面部神经和不同的组织。CNC细胞是多能干细胞，可产生骨骼、软骨、神经、牙齿、神经胶质细胞、黑色素细胞和面部结缔组织。控制它们的迁移、分化和增殖的信号仍然仅部分地被理解，尽管仅少数细胞外信号传导网络的重要性，例如Sonic hedgehog（Shh）、骨形态发生蛋白（Bmp）、成纤维细胞生长因子（Fgf）和Wnt/β-连环蛋白信号传导已被充分确立。这些通路在发育过程中以重复的方式使用，因此它们的信号传导活动的地点、时间和持续时间都很重要。