Role of environmental factors on the alteration of skeletal muscle energy metabolism and insulin sensitivity

环境因素对骨骼肌能量代谢和胰岛素敏感性改变的作用

• 批准号: RGPIN-2015-06263
• 负责人: Aguer, Céline
• 金额: $ 2.4万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590950
• 关键词: Role; environmental; factors; alteration; skeletal

The overarching goal of my lab is to better understand skeletal muscle metabolism defects that results in insulin resistance. Skeletal muscle accounts for ~80% of postprandial glucose disposal and is thus the major organ of glucose uptake. My work over the last 5 years, and that of others, demonstrated that increased inflammation and oxidative stress which results in mitochondrial dysfunction is mechanistically connected with skeletal muscle insulin resistance, however the exact cause of muscle insulin resistance development is not completely understood. Environmental factors, such as inactivity and environmental chemicals, strongly contribute to insulin resistance development.

我实验室的首要目标是更好地了解导致胰岛素抵抗的骨骼肌代谢缺陷。骨骼肌占餐后葡萄糖处置的约80%，因此是葡萄糖摄取的主要器官。在过去的5年里，我和其他人的工作表明，导致线粒体功能障碍的炎症和氧化应激增加与骨骼肌胰岛素抵抗有关，但肌肉胰岛素抵抗发展的确切原因尚未完全了解。环境因素，如不活动和环境化学物质，强烈有助于胰岛素抵抗的发展。