Role of autophagy in myeloid cell differentiation and death

造血干细胞通过分化过程产生人体所有的血细胞。中性粒细胞是终末分化骨髓细胞的一个例子，是白细胞中数量最多的一种，在宿主防御中起着至关重要的作用。每天有1000亿个中性粒细胞从骨髓中释放出来，以取代等量的死亡中性粒细胞。因此，中性粒细胞分化、生成或死亡（即细胞凋亡）的不平衡可导致许多有害的宿主效应。

Hematopoietic stem cells generate all the blood cells in the human body through the process of differentiation. Neutrophils, an example of terminally differentiated myeloid cells, are the most abundant type of white blood cell and play a crucial role in host defence. Each day 100 billion neutrophils are released from bone marrow to replace the equivalent number of dying neutrophils. Thus, an imbalance in neutrophil differentiation, generation or death (i.e., apoptosis) can result in numerous detrimental host effects.