Role of autophagy in myeloid cell differentiation and death

自噬在骨髓细胞分化和死亡中的作用

• 批准号: RGPIN-2015-06433
• 负责人: Spagnuolo, Paul
• 金额: $ 2.19万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629351
• 关键词: Role; autophagy; myeloid; cell; differentiation

Hematopoietic stem cells generate all the blood cells in the human body through the process of differentiation. Neutrophils, an example of terminally differentiated myeloid cells, are the most abundant type of white blood cell and play a crucial role in host defence. Each day 100 billion neutrophils are released from bone marrow to replace the equivalent number of dying neutrophils. Thus, an imbalance in neutrophil differentiation, generation or death (i.e., apoptosis) can result in numerous detrimental host effects.

造血干细胞通过分化过程产生人体内所有的血细胞。中性粒细胞是终末分化的髓系细胞的一个例子，是最丰富的白细胞类型，在宿主防御中发挥着关键作用。每天有1000亿个中性粒细胞从骨髓中释放出来，以取代等量的死亡中性粒细胞。因此，中性粒细胞分化、生成或死亡(即细胞凋亡)的不平衡可能导致许多有害的宿主效应。