Development of polymer biomaterials that respond to stimuli

开发对刺激作出反应的高分子生物材料

• 批准号: RGPIN-2015-06646
• 负责人: Wells, Laura
• 金额: $ 1.82万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=591195
• 关键词: Development; polymer; biomaterials; respond; stimuli

With the aging population in Canada, there is a critical need for medical devices that effectively deliver therapeutics, regenerate tissue, and replace the function of failing organs. For the successful implementation of polymer biomaterial devices to meet these needs, polymers should be designed so they can be changed (optimized) over time by external stimuli or adapt to changes in their biological environment. For example, polymer devices designed to deliver drugs at rates that may be changed over time could provide optimized treatments to individuals. The proposed research will develop new polymers that can change in response to light because it is a non-invasive external stimulus, and new materials that bind or are triggered to change in response to proteins because proteins fluctuate with diseases.

随着加拿大人口的老龄化，迫切需要有效提供治疗，再生组织并取代衰竭器官功能的医疗设备。为了成功实施聚合物生物材料器械以满足这些需求，聚合物的设计应使其能够随着时间的推移通过外部刺激而改变（优化）或适应其生物环境的变化。 例如，设计成以可能随时间改变的速率递送药物的聚合物装置可以为个体提供优化的治疗。 拟议的研究将开发新的聚合物，这些聚合物可以响应光而变化，因为它是一种非侵入性的外部刺激，以及新的材料，这些材料可以结合或触发蛋白质的变化，因为蛋白质会随着疾病而波动。