Understanding prokaryotic small proteins from context

从背景理解原核小蛋白

• 批准号: FT230100724
• 负责人: Dr Luis Pedro Coelho
• 金额: $ 67.46万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-11-01 至 2027-10-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100724
• 关键词: Understanding; prokaryotic; small; proteins; context

Prokaryotic small proteins are increasingly recognised to play important biological roles but have been largely overlooked due to the lack of adequate tools to study them. This project aims to develop new methods to identify and predict the functions of small proteins from microbial communities by studying sequence patterns in their genomes. These predicted functions will be confirmed in the laboratory, leading to a catalogue of newly characterised small proteins from a diverse range of habitats and geographies. By creating new ways to study the role of small proteins in the global microbiome, we will provide the foundational knowledge required to leverage these proteins for use in biotechnology.

人们越来越认识到原核生物小蛋白发挥着重要的生物学作用，但由于缺乏足够的工具来研究它们，在很大程度上被忽视了。该项目旨在通过研究微生物基因组中的序列模式，开发新的方法来识别和预测微生物群落中的小蛋白的功能。这些预测的功能将在实验室中得到证实，从而产生一份来自不同栖息地和地理范围的新鉴定的小蛋白目录。通过创造新的方法来研究小蛋白质在全球微生物群中的作用，我们将提供利用这些蛋白质在生物技术中使用所需的基础知识。