Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
基本信息
- 批准号:10879449
- 负责人:
- 金额:$ 15.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:ADAR1Antiviral ResponseArthropodsBiochemicalBiochemistryBiogenesisBiologicalBiological AssayBiologyC-terminalCRISPR screenCaveolaeCellsClustered Regularly Interspaced Short Palindromic RepeatsComplementComplexCytoplasmDeaminationDetectionEscape MutantEukaryotic CellEventExcisionFamilyFluorescenceFutureGenerationsImmunoprecipitationInfectionIntegration Host FactorsInterferon Type IInterferonsInvertebratesLifeMammalsMediatingMediatorMicroRNAsMolecularMolecular BiologyMolecular WeightPathway interactionsPhosphotransferasesPhysiologicalPlantsPlayPositioning AttributeProcessProkaryotic CellsProtein IsoformsProteinsProto-Oncogene Proteins c-aktRNARNA EditingRNA InterferenceRNA VirusesRNA metabolismRNA-Induced Silencing ComplexRecombinantsRibonuclease IIIRoleSendai virusSignal TransductionSiteSmall RNASpecificityStructureSystemTerminator CodonTestingTherapeuticTranscriptTranslationsTreesVariantVertebratesViralViral ProteinsVirusVirus DiseasesWorkantagonistcaveolin 1experimental studyhomologous recombinationinventionmembernovelnucleasepathogenresponseviral RNAwhole genome
项目摘要
PROJECT SUMMARY
The means by which cells respond to virus infection is critical for survival. Moreover, the cellular response to
virus differs dramatically depending on its position on the tree of life. This observation suggests that there are
many successful strategies to inhibit virus infection, just as there are many viral antagonists that have evolved
to interfere with them. Interestingly, while the cellular response to virus infection in mammals is primarily
mediated by the family of Type I interferons (IFN-I), we recently characterized an IFN-I-independent defense
system that involves an evolutionary conserved RNAse III nuclease. We find that this nuclease, called Drosha,
rapidly translocates to the cytoplasm in response to virus infection and forms a high molecular weight structure
by associating with the RNA-induced silencing complex (RISC) which we have termed the ADAR-RISC Complex
or simply, ARC. Here we seek to better understand the physiological relevance of this complex.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Benjamin R. tenOever其他文献
RNA viruses and the host microRNA machinery
RNA 病毒与宿主微小 RNA 机制
- DOI:
10.1038/nrmicro2971 - 发表时间:
2013-02-15 - 期刊:
- 影响因子:103.300
- 作者:
Benjamin R. tenOever - 通讯作者:
Benjamin R. tenOever
Benjamin R. tenOever的其他文献
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{{ truncateString('Benjamin R. tenOever', 18)}}的其他基金
Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
- 批准号:
10494390 - 财政年份:2022
- 资助金额:
$ 15.76万 - 项目类别:
Characterizing a transcriptional control region within the Type I interferon gene cluster
表征 I 型干扰素基因簇内的转录控制区域
- 批准号:
10624947 - 财政年份:2022
- 资助金额:
$ 15.76万 - 项目类别:
Characterizing a transcriptional control region within the Type I interferon gene cluster
表征 I 型干扰素基因簇内的转录控制区域
- 批准号:
10506860 - 财政年份:2022
- 资助金额:
$ 15.76万 - 项目类别:
Defining the Biology of the ADAR1-RISC Complex
定义 ADAR1-RISC 复合体的生物学
- 批准号:
10631184 - 财政年份:2022
- 资助金额:
$ 15.76万 - 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
- 批准号:
10557136 - 财政年份:2020
- 资助金额:
$ 15.76万 - 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
- 批准号:
10524881 - 财政年份:2020
- 资助金额:
$ 15.76万 - 项目类别:
Small viral RNAs as determinants of influenza A virus pathogenesis
小病毒 RNA 作为甲型流感病毒发病机制的决定因素
- 批准号:
10097984 - 财政年份:2020
- 资助金额:
$ 15.76万 - 项目类别:
Stemness and the cellular response to virus infection
干性和细胞对病毒感染的反应
- 批准号:
9528170 - 财政年份:2018
- 资助金额:
$ 15.76万 - 项目类别:
The biology of the nuclear export protein in influenza A virus replication
甲型流感病毒复制中核输出蛋白的生物学
- 批准号:
9975684 - 财政年份:2017
- 资助金额:
$ 15.76万 - 项目类别:
The mammalian small RNA machinery and its role in antiviral defenses
哺乳动物小RNA机制及其在抗病毒防御中的作用
- 批准号:
8967559 - 财政年份:2014
- 资助金额:
$ 15.76万 - 项目类别:
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