Force-sharing among synergistic muscles and mechanical properites of skeletal muscles

协同肌之间的力共享和骨骼肌的机械特性

• 批准号: 36674-2013
• 负责人: Herzog, Walter
• 金额: $ 8.39万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593028
• 关键词: Force; sharing; among; synergistic; muscles

More than half a century ago, A. Huxley developed the cross-bridge theory of muscle contraction, a theory that is represented in current textbooks of anatomy and physiology. According to the cross-bridge theory, muscle shortening occurs through the relative sliding of two sets of filaments, actin and myosin. This sliding is produced by cross-bridges that protrude from the myosin filament, attach cyclically to actin, and pull actin past the myosin filament. Although this theory has served our understanding of how muscles work well, it was known from the very beginning that basic properties of muscle contraction could not be predicted with this theory. Over the past ten years, we have studied these "unexplained" properties and concluded that the two filament thinking of muscle force production needs revision, and that a third filament, the molecular spring titin, needs to be added to our thinking of muscle contraction and force production.

半个多世纪前，A.赫胥黎提出了肌肉收缩的跨桥理论，这一理论在当前的解剖学和生理学教科书中得到了体现。根据跨桥理论，肌肉缩短是通过两组肌动蛋白和肌球蛋白的相对滑动而发生的。这种滑动是由从肌球蛋白丝伸出的跨桥产生的，周期性地附着在肌动蛋白上，并将肌动蛋白拉过肌球蛋白丝。尽管该理论有助于我们理解肌肉如何良好运作，但从一开始就知道该理论无法预测肌肉收缩的基本特性。在过去的十年里，我们研究了这些“无法解释”的特性，并得出结论：肌肉力量产生的两条细丝思维需要修正，而第三条细丝，即分子弹簧肌动蛋白，需要添加到我们关于肌肉收缩和力量产生的思维中。