Regulation of Lipid Metabolism and Vesicular Trafficking by the Oxysterol Binding Protein Kes1

氧甾醇结合蛋白 Kes1 对脂质代谢和囊泡运输的调节

• 批准号: 203103-2012
• 负责人: McMaster, Christopher
• 金额: $ 2.91万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593762
• 关键词: Regulation; Lipid; Metabolism; Vesicular; Trafficking

Each cell is surrounded by a membrane that isolates the cell from surrounding cells and its external environment. Inside each cell are more membranes that further divide the cell into individual compartments that perform specific functions (eg. duplicating genes, making energy, or getting rid of unwanted or used up cellular garbage). Think of the cell membrane as the outside of a ball and each compartment as smaller balls inside the larger one. As a cell grows and divides to make another cell the membranes of the cell need to be synthesized and transported from their site of synthesis inside the cell to the cell surface to allow for cell growth. How cell membrane synthesis is coordinated with their transport is poorly understood. The research proposed in this grant application aims to determine what the processes that allow a cell to coordinate cell growth with the transport of cell membranes to its surface so that cell growth and membrane synthesis and transport are properly synchronized. This is basic cell biology textbook knowledge that we currently lack. This grant proposes to fill major gaps in our understanding of cell biology.

每个细胞周围都有一层膜，将细胞与周围的细胞及其外部环境隔离开来。每个细胞内部有更多的膜，这些膜进一步将细胞分成执行特定功能的各个隔室(例如，复制基因，制造能量，或处理不需要的或用完的细胞垃圾)。把细胞膜想象成球的外面，每个隔室就是大球里面的小球。当一个细胞生长和分裂以形成另一个细胞时，需要合成细胞膜，并将其从细胞内的合成部位运输到细胞表面，以允许细胞生长。细胞膜的合成如何与它们的运输相协调还知之甚少。在这项拨款申请中提出的研究旨在确定允许细胞协调细胞生长与细胞膜到其表面的运输，从而使细胞生长和膜的合成和运输适当同步的过程。这是我们目前缺乏的基本细胞生物学教科书知识。这项拨款建议填补我们对细胞生物学理解的主要空白。