Conformational Switching and Energetics in the Maltose Transporter

麦芽糖转运蛋白的构象转换和能量学

• 批准号: 217494-2013
• 负责人: Shilton, Brian
• 金额: $ 3.64万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594002
• 关键词: Conformational; Switching; Energetics; Maltose; Transporter

Living cells are delimited by membranes that restrict the movement of molecules between the cell's cytoplasm and the external environment. Cells must grow, divide, and communicate with each other, and to accomplish these things, molecules must be transported across the membrane. Membrane transporters are protein machines that are embedded in the membrane and use energy to move specific molecules into or out of the cell. The proposed research is focussed on understanding the function of a group of transport systems that bacteria use to acquire nutrients from their environment.

活细胞由限制细胞质和外部环境之间分子运动的膜界定。细胞必须生长，分裂，并相互交流，为了完成这些事情，分子必须穿过膜。膜转运蛋白是嵌入在膜中的蛋白质机器，并使用能量将特定分子移入或移出细胞。这项研究的重点是了解细菌从环境中获取营养物质的一组运输系统的功能。