Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
基本信息
- 批准号:227682-2012
- 负责人:
- 金额:$ 1.97万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is not well understood how soft (muscle, fat) and rigid (bone) tissues interact to attenuate potentially injurious impact forces (shock) as they propagate through body segments to more proximal anatomical structures, following activities such as heel landings during running and arresting the body with outstretched upper extremities after falling. Activities such as these are commonly experienced by Canadians and the negative consequences of the associated impacts can be profound. Our understanding of how tissues interact to mitigate the detrimental effects of impact shock will improve as a result of this research by: 1. establishing an inventory of soft and rigid tissue masses by developing and validating prediction equations for the extremity, trunk, and head and neck segments of a wide range of people (e.g. young vs. older people). This will dramatically enhance our ability to biomechanically model the response of all segment tissues following impact; 2. further evaluating innovative methods for delivering and controlled impacts to living participants and human specimens that more closely mimic typical landing and fall arrest impact conditions, and; 3. utilizing various imaging and modeling approaches to quantify the response of soft and rigid tissues and document shock propagation pathways through these tissues after impact. From this work, it is anticipated that the biomechanics community will learn considerably about how tissues respond and interact during common activities involving impact. We will also be able to better evaluate and model the human response due to the improved realism of impact delivery and capacity to document how shock experienced during these activities propagates through segment tissues. Taken together, the outcomes of this research will significantly foster the progression of impact biomechanics research in this area and ultimately provide direction for assessing and improving injury prevention strategies and reducing healthcare costs associated with impact-induced injuries, that will benefit all Canadians.
目前还不太清楚软(肌肉、脂肪)和硬(骨)组织如何相互作用,以减弱潜在的有害冲击力(冲击),因为它们通过身体各节传播到更近端的解剖结构,比如跑步时脚跟着地和摔倒后上肢伸展阻止身体。诸如此类的活动是加拿大人经常经历的,相关影响的消极后果可能是深远的。我们对组织如何相互作用以减轻冲击的有害影响的理解将由于这项研究而得到改善:1。通过开发和验证各种人群(例如年轻人与老年人)的四肢、躯干和头颈部部分的预测方程,建立软性和刚性组织肿块的清单。这将极大地提高我们对所有节段组织在撞击后的反应进行生物力学建模的能力;2. 进一步评估向活着的参与者和人类标本提供和控制冲击的创新方法,这些方法更接近模拟典型的着陆和坠落阻止冲击条件;3. 利用各种成像和建模方法来量化软性和刚性组织的反应,并记录冲击后这些组织的冲击传播途径。从这项工作中,预计生物力学界将大大了解组织在涉及撞击的常见活动中如何反应和相互作用。我们还将能够更好地评估和模拟人类的反应,因为冲击传递的现实性得到了提高,并且有能力记录在这些活动中所经历的冲击如何通过节段组织传播。综上所述,本研究的结果将显著促进该领域冲击生物力学研究的进展,并最终为评估和改进伤害预防策略以及减少与冲击引起的伤害相关的医疗费用提供方向,这将使所有加拿大人受益。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrews, David其他文献
Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies.
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10.1016/j.ijrobp.2008.08.050 - 发表时间:
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Is the pub still the hub?
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10.1108/09596111211226815 - 发表时间:
2012-01-01 - 期刊:
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Improving the customer experience through consistency and effective service delivery in the United Kingdom public house sector
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10.1108/bfj-07-2016-0326 - 发表时间:
2017-01-01 - 期刊:
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Left ventricular remodelling in rheumatic heart disease - trends over time and implications for follow-up in childhood.
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10.1186/s12872-023-03497-0 - 发表时间:
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MacDonald, Bradley;Tarca, Adrian;Causer, Louise;Maslin, Katie;Bruce, Di;Schreiber-Wood, Rachel;Kumar, Mohit;Ramsay, James;Andrews, David;Budgeon, Charley;Katzenellenbogen, Judith;Bowen, Asha C.;Carapetis, Jonathan;Friedberg, Mark K.;Yim, Deane - 通讯作者:
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Small molecules reveal an alternative mechanism of Bax activation
- DOI:
10.1042/bcj20160118 - 发表时间:
2016-04-15 - 期刊:
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Brahmbhatt, Hetal;Uehling, David;Andrews, David - 通讯作者:
Andrews, David
Andrews, David的其他文献
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{{ truncateString('Andrews, David', 18)}}的其他基金
Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
- 批准号:
227682-2012 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
- 批准号:
227682-2012 - 财政年份:2014
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
- 批准号:
227682-2012 - 财政年份:2013
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
- 批准号:
227682-2012 - 财政年份:2012
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modeling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2006 - 财政年份:2010
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modeling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2006 - 财政年份:2009
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modeling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2006 - 财政年份:2008
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modeling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2006 - 财政年份:2007
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modeling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2006 - 财政年份:2006
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Non-rigid modelling of the human musculoskeletal system
人体肌肉骨骼系统的非刚性建模
- 批准号:
227682-2001 - 财政年份:2005
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
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Soft and rigid tissue effects on shock propagation.
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- 批准号:
227682-2012 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
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软组织和硬组织对冲击传播的影响。
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Discovery Grants Program - Individual
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227682-2012 - 财政年份:2013
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$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Soft and rigid tissue effects on shock propagation.
软组织和硬组织对冲击传播的影响。
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- 资助金额:
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