Design and characterization of a new microCT/radiotherapy system

新型 microCT/放射治疗系统的设计和表征

• 批准号: 238542-2011
• 负责人: Bentourkia, Mhamed
• 金额: $ 1.09万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594163
• 关键词: Design; characterization; new; microCT; radiotherapy

Medical imaging is used to diagnose diverse types of diseases, for patient follow-up, and for pharmacological studies. Even computed tomography (CT) utilizes X-ray radiations, it is however the most widespread due to its compact size, the ease of its operation, its simple maintenance and its non-confinement. Meanwhile, CT has a limited functionality with respect to other medical imaging modalities based on radioisotopes. CT provides quantitative 3D static or dynamic images, in a rapid and non-invasive fashion with a very high spatial resolution. With the injection of contrast agents, CT can provide dynamic morphological information in tissue and organs. In the present research project, we propose the design of a microCT for small animals, rapid (30 images/sec) and at high spatial resolution (100 microns). The X-ray source (SX), a microfocus, provides a variable energy for imaging different tissues and a focal point size of 13 to 20 microns performing very high spatial resolution. The detecting system is formed by a flat panel detector (PD) of 24 cm x 12 cm accommodating a rat of 400 g. Furthermore, in the proposed architecture, the animal bed can be displaced at three positions and the PD at two positions for image magnification when measuring small organs in rats and mice. The whole system SX and PD rotates at 360o around the animal to obtain a 3D volume images. The other original characteristic of our setup is that we want to treat tumors implanted in small animals with this same X-ray source and by taking advantage of the precision on the tumor localization with our scanner. Therefore, the tumor is also precisely localized depending on angle views in addition to the displacement of the animal with respect to SX to better target the tumor. With the utilization of usual contrast agents, or those to be developed with our collaborators, we will work on the quantification of the dynamic measures to calculate the physiological parameters in diverse organs and tissues, and for pharmacological studies.

医学成像用于诊断不同类型的疾病，用于患者随访和药理学研究。即使计算机断层扫描（CT）利用X射线辐射，但由于其紧凑的尺寸，易于操作，维护简单和无限制，它是最广泛的。同时，CT相对于基于放射性同位素的其他医学成像模态具有有限的功能。CT以快速和非侵入性的方式提供定量3D静态或动态图像，具有非常高的空间分辨率。通过注射对比剂，CT可以提供组织和器官的动态形态学信息。在目前的研究项目中，我们提出了一种用于小动物的microCT的设计，快速（30图像/秒）和高空间分辨率（100微米）。X射线源（SX）是一种微焦点，为不同组织成像提供可变能量，焦点尺寸为13至20微米，具有极高的空间分辨率。检测系统由容纳400 g大鼠的24 cm x 12 cm平板检测器（PD）形成。此外，在所提出的架构，动物床可以在三个位置和PD在两个位置的图像放大时，测量大鼠和小鼠的小器官。整个系统SX和PD围绕动物360 °旋转，以获得3D体积图像。我们设备的另一个原始特征是，我们希望用相同的X射线源治疗植入小动物体内的肿瘤，并利用我们的扫描仪在肿瘤定位上的精确度。因此，除了动物相对于SX的位移之外，还根据角度视图精确定位肿瘤以更好地靶向肿瘤。利用常规造影剂或与我们的合作者开发的造影剂，我们将致力于动态测量的量化，以计算不同器官和组织的生理参数，并用于药理学研究。