Development of continuous multiphase microreactors for the production of fine chemicals

开发用于精细化学品生产的连续多相微反应器

• 批准号: 261677-2013
• 负责人: Macchi, Arturo
• 金额: $ 2.11万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594627
• 关键词: Development; continuous; multiphase; microreactors; production

Many fine chemicals and pharmaceuticals are produced by solvent-intensive batch or semi-batch processes increasing costs and environmental impact. In comparison, continuous-flow microreactors offer a large surface-to-volume ratio and intimate contact between reactants, which leads to very high heat and mass transfer rates, permitting improved reaction control and selectivity at more severe operating conditions. This and their small volume enable safer handling of hazardous reactions and unstable intermediates. The overall goal of this research program is thus to develop continuous-flow microreactor technology sufficiently flexible that it can outperform batch/semi-batch reactors for a variety of single and multiphase reactions over production scales ranging from pharmaceutical clinical trial phases I (10-50 ml/min) to III (400-600 ml/min). Focus is primarily on molecules where synthesis is highly exothermic and/or limited by interphase mass transfer since these operating conditions are more difficult to optimize.

许多精细化学品和药品是通过溶剂密集型间歇或半间歇工艺生产的，这增加了成本和环境影响。相比之下，连续流微反应器提供大的表面积与体积比和反应物之间的紧密接触，这导致非常高的传热和传质速率，从而允许在更严格的操作条件下改善反应控制和选择性。这一点和它们的小体积使危险反应和不稳定中间体的处理更安全。因此，该研究计划的总体目标是开发足够灵活的连续流微反应器技术，使其在从药物临床试验阶段I（10-50 ml/min）到III（400-600 ml/min）的生产规模上，能够在各种单相和多相反应中优于间歇/半间歇反应器。重点主要放在合成是高度放热和/或受相间传质限制的分子上，因为这些操作条件更难以优化。