Development of continuous multiphase microreactors for the production of fine chemicals

开发用于精细化学品生产的连续多相微反应器

• 批准号: 261677-2013
• 负责人: Macchi, Arturo
• 金额: $ 2.11万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571112
• 关键词: Development; continuous; multiphase; microreactors; production

Many fine chemicals and pharmaceuticals are produced by solvent-intensive batch or semi-batch processes increasing costs and environmental impact. In comparison, continuous-flow microreactors offer a large surface-to-volume ratio and intimate contact between reactants, which leads to very high heat and mass transfer rates, permitting improved reaction control and selectivity at more severe operating conditions. This and their small volume enable safer handling of hazardous reactions and unstable intermediates. The overall goal of this research program is thus to develop continuous-flow microreactor technology sufficiently flexible that it can outperform batch/semi-batch reactors for a variety of single and multiphase reactions over production scales ranging from pharmaceutical clinical trial phases I (10-50 ml/min) to III (400-600 ml/min). Focus is primarily on molecules where synthesis is highly exothermic and/or limited by interphase mass transfer since these operating conditions are more difficult to optimize. A systematic and thorough experimental program will investigate: 1) Hydrodynamics and transport phenomena of gas-liquid flow without and with solid-supported catalyst in select and distinct reactor geometries. This will lead to criteria for choosing mixing structures based on desired contacting pattern and efficiency in dissipating energy, and to robust scaling rules. 2) Ring-closing metathesis of olefins and hydrogenation of nitriles, which are catalytic reactions of central importance in organic synthesis and take advantage of leading chemical expertise at the University of Ottawa. This will synergistically use and provide information towards part 1); forming stronger ties between chemists and engineers such that catalyst/reaction and reactor design are optimized concurrently. Deploying graduate students trained within a multidisciplinary science/engineering environment will help accelerate changes to manufacturing in the pharmaceutical industry, an important contributor to Canada's economy and well-being.

许多精细化学品和药品是通过溶剂密集型间歇或半间歇工艺生产的，增加了成本和对环境的影响。相比之下，连续流微反应器提供了大的表面积与体积比和反应物之间的紧密接触，这导致了非常高的传热和传质速率，从而在更恶劣的操作条件下改善了反应控制和选择性。它及其体积小，能够更安全地处理危险反应和不稳定的中间体。因此，这项研究计划的总体目标是开发足够灵活的连续流动微反应器技术，使其在从药物临床试验I阶段(10-50毫升/分钟)到III阶段(400-600毫升/分钟)的生产规模上，在各种单相和多相反应中的表现优于间歇/半间歇反应器。由于这些操作条件更难优化，因此主要关注合成高度放热和/或受相间传质限制的分子。 系统而深入的实验计划将研究：1)在选择和不同的反应器结构中，没有和有固体载体催化剂的气液两相流动的流体力学和传输现象。这将导致基于所需的接触模式和能量耗散效率来选择混合结构的标准，以及稳健的比例规则。2)烯烃的开环歧化反应和氰化物的加氢反应，这是有机合成中最重要的催化反应，利用了渥太华大学领先的化学专业知识。这将协同使用并为第1部分提供信息)；在化学家和工程师之间建立更紧密的联系，从而同时优化催化剂/反应和反应器设计。部署在多学科科学/工程环境中培训的研究生将有助于加快制药业制造的变革，制药业是加拿大经济和福祉的重要贡献者。