Development of continuous multiphase microreactors for the production of fine chemicals

开发用于精细化学品生产的连续多相微反应器

• 批准号: 261677-2013
• 负责人: Macchi, Arturo
• 金额: $ 2.11万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571112
• 关键词: Development; continuous; multiphase; microreactors; production

Many fine chemicals and pharmaceuticals are produced by solvent-intensive batch or semi-batch processes increasing costs and environmental impact. In comparison, continuous-flow microreactors offer a large surface-to-volume ratio and intimate contact between reactants, which leads to very high heat and mass transfer rates, permitting improved reaction control and selectivity at more severe operating conditions. This and their small volume enable safer handling of hazardous reactions and unstable intermediates. The overall goal of this research program is thus to develop continuous-flow microreactor technology sufficiently flexible that it can outperform batch/semi-batch reactors for a variety of single and multiphase reactions over production scales ranging from pharmaceutical clinical trial phases I (10-50 ml/min) to III (400-600 ml/min). Focus is primarily on molecules where synthesis is highly exothermic and/or limited by interphase mass transfer since these operating conditions are more difficult to optimize. A systematic and thorough experimental program will investigate: 1) Hydrodynamics and transport phenomena of gas-liquid flow without and with solid-supported catalyst in select and distinct reactor geometries. This will lead to criteria for choosing mixing structures based on desired contacting pattern and efficiency in dissipating energy, and to robust scaling rules. 2) Ring-closing metathesis of olefins and hydrogenation of nitriles, which are catalytic reactions of central importance in organic synthesis and take advantage of leading chemical expertise at the University of Ottawa. This will synergistically use and provide information towards part 1); forming stronger ties between chemists and engineers such that catalyst/reaction and reactor design are optimized concurrently. Deploying graduate students trained within a multidisciplinary science/engineering environment will help accelerate changes to manufacturing in the pharmaceutical industry, an important contributor to Canada's economy and well-being.

许多精细的化学物质和药物都是由溶剂密集型批次或半批量工艺产生的，增加了成本和环境影响。相比之下，连续流微反应器提供了较大的表面体积比和反应物之间的亲密接触，这会导致非常高的热量和传质速率，从而在更严重的工作条件下提高了反应控制和选择性。这及其少量能够更安全地处理危险反应和不稳定的中间体。因此，该研究计划的总体目标是开发出足够灵活的连续流动微反应器技术，以便在生产量表上，它可以优于各种单一和多阶段反应器，从制药临床试验阶段I（10-50 mL/min）到III（400-600 mL/min/min）。重点主要放在合成高度放热和/或受相间质量转移限制的分子上，因为这些工作条件更难优化。 系统且彻底的实验计划将研究：1）在选择和不同反应器几何形状中没有固体支持的催化剂的气体流动流动和运输现象。这将导致根据所需的接触模式和耗散能量的效率选择混合结构的标准，以及稳定的缩放规则。 2）烯烃的环插入和硝酸盐的氢化，这是有机合成中核心重要性的催化反应，并利用渥太华大学的领先化学专业知识。这将协同使用并提供第1部分的信息；在化学家和工程师之间形成更强的联系，以便同时优化催化剂/反应器设计。在多学科科学/工程环境中培训的研究生将有助于加速制药行业制造业的变化，这是加拿大经济和福祉的重要贡献。