Cellular function of galectin-7: a critical role in mitochondrial apoptosis

Galectin-7 的细胞功能：在线粒体凋亡中的关键作用

• 批准号: 298215-2013
• 负责人: StPierre, Yves
• 金额: $ 2.62万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594879
• 关键词: Cellular; function; galectin; critical; role

Apoptosis is an indispensable part of the development and function of an organism. In this process, cells that are no longer needed or that will be detrimental to an organism or tissue are disposed of in a neat and orderly manner to ensure that the damaged cell is packaged and removed cleanly. Among the proteins that play an important role in apoptosis, we find proteins of the bcl-2 family. Members of this family share several structural features that allow them to bind to other intracellular proteins. Our research program aims at better understanding how Bcl-2 proteins interact with galectins.

细胞凋亡是生物体发育和功能不可缺少的一部分。在这个过程中，不再需要的细胞或对生物体或组织有害的细胞以整洁有序的方式处理，以确保受损细胞被包装并干净地去除。在细胞凋亡中起重要作用的蛋白质中，我们发现了bcl-2家族的蛋白质。这个家族的成员有几个共同的结构特征，使它们能够与其他细胞内蛋白质结合。我们的研究计划旨在更好地了解Bcl-2蛋白如何与半乳糖凝集素相互作用。