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Elucidation of the molecular mechanisms governing currently untargeted RAS effector pathways towards novel therapeutic approaches for the most refractory human cancers

Elucidation of the molecular mechanisms governing currently untargeted RAS effector pathways towards novel therapeutic approaches for the most refractory human cancers
阐明目前非靶向 RAS 效应通路的分子机制,为最难治性人类癌症提供新的治疗方法
批准号:
343870
负责人:
Smith Matthew J
金额:
$58.76万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2021-03-01

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中文摘要
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英文摘要
Cancers are driven by abnormal changes to the genetic material of various cell types in the human body. These changes frequently result in the production of mutated proteins, or an overproduction of proteins, leading to unregulated cell growth. The protei
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Regulation of RAS driven cellular proliferation by SHOC2 and the MRAS GTPase
Investigation into RAS GTPase control of cell adhesion and proliferation through alternative downstream effectors
Canada Research Chair - Tier 2
  • 批准号:
    459703
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2021
  • 负责人:
    Smith Matthew J
  • 依托单位:
Canada Research Chair Tier 2
  • 批准号:
    373614
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2016
  • 负责人:
    Smith Matthew J
  • 依托单位:
海外基金