Modulation of T cell activation by the Beta2-Adrenergic Receptor

Beta2 肾上腺素受体对 T 细胞活化的调节

• 批准号: 418522-2013
• 负责人: Darlington, Peter
• 金额: $ 2.33万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596400
• 关键词: Modulation; cell; activation; Beta2; Adrenergic

BACKGROUND: Adaptive immune responses are coordinated by T lymphocytes, a white blood cell that circulates through blood and lymphatics of most vertebrate animals. One area that has not been widely explored is the effects of stress-activated hormones such as catecholamines, for example noradrenaline and adrenaline. T lymphocytes can sense catecholamines through a receptor called the beta2-adrenergic receptor, but how this alters adaptive immune responses is not very well understood.

背景：适应性免疫反应是由T淋巴细胞协调的，T淋巴细胞是一种白细胞，在大多数脊椎动物的血液和淋巴系统中循环。一个尚未被广泛探索的领域是应激激活激素的影响，如儿茶酚胺，例如去甲肾上腺素和肾上腺素。T淋巴细胞可以通过一种叫做β -肾上腺素能受体的受体感知儿茶酚胺，但是这种受体如何改变适应性免疫反应还不是很清楚。