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Understanding and harnessing the therapeutic potential of VISTA: a PD-1-like negative immune checkpoint regulator

Understanding and harnessing the therapeutic potential of VISTA: a PD-1-like negative immune checkpoint regulator
了解并利用 VISTA 的治疗潜力：一种类似 PD-1 的阴性免疫检查点调节剂
批准号：
344293
负责人：
Gariepy Jean
金额：
$55.14万
依托单位：
Sunnybrook Research Institute (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-03-01 至 2021-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=344293&lang=en
关键词：
Anti-Inflammatory Agents Aptamers Cancer Immune Checkpoint Inhibitors Immunomodulation Immunotherapy Mass Spectrometry Osteoarthritis Protein Therapeutics Receptor Identification

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中文摘要
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英文摘要
Activating or dampening immune responses are events that are triggered by the binding of co-stimulatory and co-inhibitory molecular partners expressed on T cells, antigen-presenting cells and cancer cells. The uncontrolled activation of immune responses
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会议论文
Development of gastrointestinal track-targeted biologics to improve the treatment of inflammatory bowel disease (IBD)
Discovery and development of VISTA antagonists that restore antitumor immunity
Design and in vivo delivery of novel anti-inflammatory agents
Targeted imaging and therapy of breast cancers using Tn antigen-specific DNA aptamers
  • 批准号：
    187558
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2009
  • 负责人：
    Gariepy Jean
  • 依托单位：
    University Health Network (Toronto)
国内基金
海外基金
Aptamers新型分子探针的构建及对乳腺癌超早期MR诊断的实验研究