Improving the efficacy of pressurized metered dose inhaler spacers

提高加压定量吸入器储雾器的功效

• 批准号: 472717-2014
• 负责人: Arzanpour, Siamak
• 金额: $ 1.4万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=598867
• 关键词: Improving; efficacy; pressurized; metered; dose

Pressurized Metered Dose Inhalers (pMDIs) are devices used to deliver a specific amount of medication to the lungs but require perfect timing of activation and inhalation for the best efficacy. A spacer is a medical device which sits between pMDI canister and the oral cavity and allows longer drug suspension and more time for patients to slowly and deeply inhale the medication. The goal of this NSERC CRD proposal is to design the next generation of inhaler spacers to improve efficacy of drug delivery (less deposition on the spacers) and patients' convenience (extended inhalation time). The project will focus on the development of two innovative actuated pMDI spacers, the Vibrochamber and Turbochamber. First, an accurate finite element model of the drug delivery process in spacers will be developed and experimentally verified. This model will then be used for numerical simulations and optimization of the actuated spacers. Finally, prototypes of the spacers will be fabricated and tested in a standard experimental setup.

加压计量吸入器(PMDI)是用于将特定数量的药物输送到肺部的设备，但需要完美的激活和吸入时间才能获得最佳效果。间隔器是一种医疗设备，位于pMDI罐和口腔之间，允许更长的药物悬浮期和更多的时间让患者缓慢而深度地吸入药物。NSERC CRD提案的目标是设计下一代吸入器间隔器，以提高药物输送效率(减少间隔器上的沉积)和患者的便利性(延长吸入时间)。该项目将专注于开发两个创新的驱动PMDI间隔器，可控震源燃烧室和涡轮燃烧室。首先，将建立一个准确的有限元模型来描述药物在间隔器中的输送过程，并进行实验验证。然后，该模型将用于驱动间隔器的数值模拟和优化。最后，将在标准的实验装置中制造和测试间隔器的原型。