Improving the efficacy of pressurized metered dose inhaler spacers

加压计量吸入器（pmdi）是一种用于向肺部输送一定量药物的装置，但需要完美的激活和吸入时间才能达到最佳效果。间隔器是一种位于pMDI罐和口腔之间的医疗装置，它可以延长药物悬浮时间，让患者有更多的时间缓慢而深入地吸入药物。这项NSERC CRD提案的目标是设计下一代吸入器间隔物，以提高药物递送的有效性（减少间隔物上的沉积）和患者的便利性（延长吸入时间）。该项目将重点开发两种创新的驱动式pMDI隔离器：振动室和涡轮室。首先，将建立一个精确的药物在间隔器中传递过程的有限元模型并进行实验验证。该模型将用于数值模拟和优化驱动垫片。最后，将在标准实验装置中制造和测试间隔片的原型。

Pressurized Metered Dose Inhalers (pMDIs) are devices used to deliver a specific amount of medication to the lungs but require perfect timing of activation and inhalation for the best efficacy. A spacer is a medical device which sits between pMDI canister and the oral cavity and allows longer drug suspension and more time for patients to slowly and deeply inhale the medication. The goal of this NSERC CRD proposal is to design the next generation of inhaler spacers to improve efficacy of drug delivery (less deposition on the spacers) and patients' convenience (extended inhalation time). The project will focus on the development of two innovative actuated pMDI spacers, the Vibrochamber and Turbochamber. First, an accurate finite element model of the drug delivery process in spacers will be developed and experimentally verified. This model will then be used for numerical simulations and optimization of the actuated spacers. Finally, prototypes of the spacers will be fabricated and tested in a standard experimental setup.