Antigen-specific functional properties and molecular profiling of autoreactive T-cells in individuals at risk for type 1 diabetes.

有 1 型糖尿病风险的个体中自身反应性 T 细胞的抗原特异性功能特性和分子分析。

• 批准号: 346058
• 负责人: Piccirillo Ciriaco A
• 金额: $ 142.58万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=346058&lang=en
• 关键词: Antigen-Specific; Autoreactive Tcr Sequences; Biomarkers; Epigenetics; Immune Regulation; Regulatory T Cells; T Cells; Type 1 Diabetes (Recent-Onset)

Type 1 diabetes (T1D) is an autoimmune disease, resulting from the destruction of the insulin-producing beta- cells in the pancreas by the T-cells of the immune system. In recent years we have discovered over forty places in the genome, where genetic vari

1型糖尿病(T1D)是一种自身免疫性疾病，由免疫系统的T细胞破坏胰腺中产生胰岛素的β细胞引起。近年来，我们已经在基因组中发现了40多个位置，在这些位置上，遗传变异