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Antigen-specific functional properties and molecular profiling of autoreactive T-cells in individuals at risk for type 1 diabetes.

Antigen-specific functional properties and molecular profiling of autoreactive T-cells in individuals at risk for type 1 diabetes.
有 1 型糖尿病风险的个体中自身反应性 T 细胞的抗原特异性功能特性和分子分析。
批准号:
346058
负责人:
Piccirillo Ciriaco A
金额:
$142.58万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2021-03-01

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中文摘要
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英文摘要
Type 1 diabetes (T1D) is an autoimmune disease, resulting from the destruction of the insulin-producing beta- cells in the pancreas by the T-cells of the immune system. In recent years we have discovered over forty places in the genome, where genetic vari
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Modelling of human FOXP3+ regulatory T cell functional development in health and disease using artificial thymic organoids.
Viral diversity and immune escape variants in vulnerable individuals post-vaccination.
Translational control of gene expression in Foxp3+ regulatory T cell function.
  • 批准号:
    253818
  • 项目类别:
    Operating Grants
  • 资助金额:
    $56.79万
  • 财政年份:
    2012
  • 负责人:
    Piccirillo Ciriaco A
  • 依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    204192
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2008
  • 负责人:
    Piccirillo Ciriaco A
  • 依托单位: