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Modelling of human FOXP3+ regulatory T cell functional development in health and disease using artificial thymic organoids.

Modelling of human FOXP3+ regulatory T cell functional development in health and disease using artificial thymic organoids.
使用人工胸腺类器官对健康和疾病中的人类 FOXP3 调节性 T 细胞功能发育进行建模。
批准号:
488677
负责人:
Piccirillo Ciriaco A
金额:
$103.94万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01

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英文摘要
Background: Autoimmune diseases (AD) are a significant cause of chronic morbidity and disability in men and women. Multi-organ autoimmunity is a feature of Tregopathies, rare congenital diseases caused by mutations in key immune genes like FOXP3, a master
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Viral diversity and immune escape variants in vulnerable individuals post-vaccination.
Antigen-specific functional properties and molecular profiling of autoreactive T-cells in individuals at risk for type 1 diabetes.
Translational control of gene expression in Foxp3+ regulatory T cell function.
  • 批准号:
    253818
  • 项目类别:
    Operating Grants
  • 资助金额:
    $56.79万
  • 财政年份:
    2012
  • 负责人:
    Piccirillo Ciriaco A
  • 依托单位:
CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA
  • 批准号:
    204192
  • 项目类别:
  • 资助金额:
    $36.43万
  • 财政年份:
    2008
  • 负责人:
    Piccirillo Ciriaco A
  • 依托单位:
海外基金