Rational design of non-immunogenic elastin-based materials for applications in drug delivery

成功的癌症化疗需要能够减少和消除肿瘤的强效药物达到预期目标。因为这些药物通常是有毒的，所以为了限制副作用，尽可能少地释放到身体的健康部位也是很重要的。由于这些原因，研究科学家一直在努力开发“药物运载工具”，它就像特洛伊木马一样，可以安全地穿过健康组织，将癌症药物走私到肿瘤中，在那里它们会在很长一段时间内释放出来。这些载体是微小的（纳米大小）颗粒，可以穿过血管并深入肿瘤。它们由合成材料或天然分子（如脂质）制成，脂质已经存在于我们的身体中。然而，在这些方法用于癌症治疗之前，必须解决一些重要的问题。一方面，到目前为止开发的合成颗粒往往会引发免疫反应（炎症），这导致车辆被封装在惰性组织中，有效地“埋葬”并使其丧失功能。另一方面，天然的、以脂质为基础的交通工具往往释放货物太快，限制了它们的有效性。

Successful cancer chemotherapy requires that the powerful drugs which can reduce and eliminate tumours reach their intended target. Because these drugs are usually toxic, it is also essential that as little as possible is released into healthy parts of the body in order to limit adverse side effects. For these reasons, research scientists have been trying to develop "drug delivery vehicles" which act like trojan horses that can travel safely through healthy tissues and smuggle cancer drugs into tumours, where they are released over a prolonged period of time. These vehicles are tiny (nanometer-sized) particles that can travel through blood vessels and penetrate deep into tumours. They are made either of synthetic materials or of natural molecules such as lipids, which already exist in our bodies. However, important problems must be solved before these approaches become useful in cancer therapies. On the one hand, the synthetic particles developed to this date tend to elicit an immune response (inflammation), which results in the encapsulation of the vehicles in inert tissue, effectively "burying" and disabling them. On the other hand, natural, lipid-based vehicles tend to release their cargo too quickly, limiting their effectiveness.