Graphite calorimeter probe for clinical radiation dosimetry

用于临床辐射剂量测定的石墨量热仪探头

• 批准号: 500180-2016
• 负责人: Seuntjens, Jan
• 金额: $ 9.09万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=607953
• 关键词: Graphite; calorimeter; probe; clinical; radiation

This Idea-to-Innovation proposal builds on patent-pending probe calorimeter-based technology to take significant steps to bring to market a revolutionary new, self-calibrating radiation dosimeter system. This system is useful in clinical reference determination of delivered dose in the medical application of radiation to the treatment of cancer of radiation therapy units as well as in other applications involving the accurate measurement of ionizing radiation dose. The proposal aims to refine the design and manufacturing quality of the detector system, will have the system undergo third-party validation and will provide a foundation to establish and incorporate a start-up company, called Caldose. Caldose will be the first company to make available a self-calibrating dosimetry system for applications in radiation therapy clinics, dose calibration laboratories, as well as other irradiation facilities (food processing, nuclear medicine, radiobiology, medical sterilization, security services, etc.). Since current dose measurement systems rely on calibration coefficients obtained from a primary standards dose laboratory, their accurate use is limited to a particular set of standard conditions. Any use of these devices that deviates from these calibration conditions (e.g., a realistic patient setup) must be correctly accounted, which often leads to significant uncertainty on the measured dose. Our patent-pending technology is based on calorimetric concepts that have been established over the last 60 years by standards dosimetry labs, and offers the most direct means of measuring the delivered dose at the point of care.

这一创意创新提案建立在正在申请专利的探头热量计技术的基础上，采取重大步骤，将革命性的新型自校准辐射剂量计系统推向市场。该系统在放射治疗单元的癌症治疗的放射医学应用中以及在涉及电离辐射剂量的精确测量的其他应用中的递送剂量的临床参考确定中是有用的。该提案旨在改进探测器系统的设计和制造质量，将使该系统接受第三方验证，并将为建立和合并一家名为Caldose的初创公司提供基础。Caldose将是第一家提供用于放射治疗诊所、剂量校准实验室以及其他辐照设施（食品加工、核医学、放射生物学、医疗消毒、安全服务等）的自校准剂量测定系统的公司。由于目前的剂量测量系统依赖于从一级标准剂量实验室获得的校准系数，因此其准确使用仅限于一组特定的标准条件。任何偏离这些校准条件的这些设备的使用（例如，现实的患者设置），这通常导致测量剂量的显著不确定性。我们正在申请专利的技术基于过去60年来由标准剂量测定实验室建立的量热概念，并提供了在护理点测量输送剂量的最直接方法。