Identifying fertility markers in boars

识别公猪的生育力标记

• 批准号: 506061-2016
• 负责人: Buhr, Mary
• 金额: $ 1.82万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=610071
• 关键词: Identifying; fertility; markers; boars

Boars with poor fertility cause financial losses to swine genetic companies such as Topigs Norsvin Canada Inc. and the larger Canadian swine industry, reduce the efficiency of food production, and slow the rate of genetic improvement. Currently there is no accurate test for a boar's fertility, and Topigs Norsvin Canada must provide semen to a number of customers, and collect pregnancy rates and number of pigs per litter from at least 20 inseminations from several producers before they can determine if the boar himself is subfertile. Successful identification of sub or non-fertile boars would enable Topigs Norsvin Canada Inc. to reduce costly reproductive losses and improve the overall productivity and profitability of the Canadian swine industry. The objective of this project is to identify potential markers of boar fertility to allow pre-screening of individual boars before selection into a breeding program. This will be achieved by determining the uniquely different amounts and types of a newly identified fertility-predicting protein, ATPase, in boars already proven to be of high and low fertility. Numerous Skype and in-person consultations between Topigs officials and our group have designed this exciting project to assess applicability of this technology in the Canadian industry. Differences between high and low fertility boars will be determined and these data will provide the foundation for the development of a simple functional assay to enable Topigs Norsvin Canada Inc. to proactively screen all boars within their system, and identify and remove low fertility boars from the breeding population.

生育能力差的公猪给Topigs Norsvin Canada Inc.等猪基因公司造成了经济损失。以及加拿大规模较大的养猪业，降低了粮食生产的效率，减缓了遗传改良的速度。目前还没有准确的测试公猪的生育能力，Topigs Norsvin Canada必须向一些客户提供精液，并从几个生产商那里收集至少20次授精的怀孕率和每窝猪的数量，然后才能确定公猪本身是否生育能力低下。成功识别亚生育或非生育公猪将使Topigs Norsvin Canada Inc.减少昂贵的繁殖损失，提高加拿大养猪业的整体生产力和盈利能力。本项目的目的是确定公猪生育力的潜在标记，以便在选择进入育种计划之前对个体公猪进行预筛选。这将通过确定一种新鉴定的生育力预测蛋白ATP酶的独特不同数量和类型来实现，该蛋白质已被证明具有高生育力和低生育力。Topigs官员和我们团队之间进行了多次Skype和面对面磋商，设计了这个令人兴奋的项目，以评估该技术在加拿大行业的适用性。将确定高生育力和低生育力公猪之间的差异，这些数据将为开发一种简单的功能测定法提供基础，以使Topigs Norsvin Canada Inc.主动筛查系统内的所有公猪，并从育种群体中识别和剔除低生育力公猪。