Elucidating molecular mechanisms by which seeds respond to environmental factors

阐明种子响应环境因素的分子机制

基本信息

  • 批准号:
    RGPIN-2014-03621
  • 负责人:
  • 金额:
    $ 2.48万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2016
  • 资助国家:
    加拿大
  • 起止时间:
    2016-01-01 至 2017-12-31
  • 项目状态:
    已结题

项目摘要

Plant hormones are low abundant signal molecules, which significantly influence a variety of processes in plant growth and development. Functional genomics research in cereals has revealed that key genetic loci for yield production and stress responses selected by the classical breeding include a series of hormone metabolism and signaling genes. The plant hormone metabolism is regulated by a number of environmental factors and plays an important role in tuning plant growth in response to changing environment. Current challenge in plant biology and biotechnology is to understand how plants sense the environmental factors and alter the plant hormone metabolism. The Nambara research group studies how plants control cellular concentrations of the plant hormone levels with a focus on abscisic acid (ABA) metabolism. We use Arabidopsis seed germination as a model system, because seeds have sophisticated mechanisms to sense environmental conditions. Mature, dry seeds contain all the components required to resume the plant’s life cycle in an appropriate environment. The seeds sense water, nutrients, temperature, after-ripening, and light to determine if the appropriate germination environment exists, and a change in these external cues alters plant hormone metabolism and signaling, which determine whether seeds germinate or remain dormant. The proposed research aims to elucidate the molecular mechanisms by which seeds sense environmental signals and regulate plant hormone metabolism, with a focus on how nitrate regulates ABA catabolism and seed germination. Nitrate is a major nitrogen source existing in soil and influences plant growth and development as a nutrient and as a signal. As a nutrient, nitrate is assimilated to ammonium and then incorporated into amino acids. As a signal, low nitrate concentration causes rapid reprogramming of genome-wide gene expression, even in mutants defective in nitrate assimilation. Nitrate promotes seed germination in many plant species. The effect of nitrate on germination can be observed in mutants defective in nitrate assimilation. This indicates that it acts as a signal to stimulate germination. My research group previously reported that nitrate activates ABA catabolism and reduces ABA, an inhibitor of germination. Despite recent identification of essential genes for nitrate sensing and signal transduction, the molecular mechanisms by which nitrate regulates ABA catabolism remain largely unknown. The overall goal of this grant is to investigate the molecular and cellular mechanisms involved in nitrate regulation of ABA metabolism and seed germination. My research group has recently identified the novel factor regulating these processes during Arabidopsis seed germination. We will elucidate the molecular function of the regulators in nitrate signaling in seeds. Stable crop yield under nitrate limited condition is a key target for plant biotechnology, because sustainable agricultural practices must limit expensive and potentially polluting nitrate inputs. Our basic research will help to gain a novel solution to increase crop yield and decrease crop losses.
植物激素是一种低丰度的信号分子,对植物生长发育的多种过程具有重要影响。谷物功能基因组学研究表明,经典育种选择的影响产量和胁迫反应的关键遗传位点包括一系列激素代谢和信号基因。植物激素代谢受多种环境因子的调控,在调节植物生长以适应环境变化中起着重要作用。植物生物学和生物技术目前面临的挑战是了解植物如何感知环境因素并改变植物激素代谢。南巴拉研究小组研究植物如何控制植物激素水平的细胞浓度,重点关注脱落酸(ABA)代谢。我们使用拟南芥种子发芽作为模型系统,因为种子有复杂的机制来感知环境条件。成熟、干燥的种子含有在适当的环境中恢复植物生命周期所需的所有成分。种子通过感知水分、养分、温度、成熟后和光照来确定是否存在合适的发芽环境,这些外部信号的变化会改变植物的激素代谢和信号,从而决定种子是发芽还是休眠。本研究旨在阐明种子感知环境信号和调节植物激素代谢的分子机制,重点研究硝酸盐对ABA分解代谢和种子萌发的调控作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Nambara, Eiji其他文献

Vascular system is a node of systemic stress responses Competence of the cell to synthesize abscisic acid and its responsiveness to external cues
  • DOI:
    10.4161/psb.3.12.7145
  • 发表时间:
    2008-01-01
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Endo, Akira;Koshiba, Tomokazu;Nambara, Eiji
  • 通讯作者:
    Nambara, Eiji
Stored and neosynthesized mRNA in Arabidopsis seeds: effects of cycloheximide and controlled deterioration treatment on the resumption of transcription during imbibition
  • DOI:
    10.1007/s11103-010-9603-x
  • 发表时间:
    2010-05-01
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Kimura, Mitsuhiro;Nambara, Eiji
  • 通讯作者:
    Nambara, Eiji
Drought induction of Arabidopsis 9-cis-epoxycarotenoid dioxygenase occurs in vascular parenchyma cells
  • DOI:
    10.1104/pp.108.116632
  • 发表时间:
    2008-08-01
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Endo, Akira;Sawada, Yoshiaki;Nambara, Eiji
  • 通讯作者:
    Nambara, Eiji
Storage proteins.
  • DOI:
    10.1199/tab.0020
  • 发表时间:
    2002-01-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fujiwara, Toru;Nambara, Eiji;Naito, Satoshi
  • 通讯作者:
    Naito, Satoshi
Persistence of Abscisic Acid Analogs in Plants: Chemical Control of Plant Growth and Physiology.
植物中脱甲酸类似物的持久性:植物生长和生理学的化学控制。
  • DOI:
    10.3390/genes14051078
  • 发表时间:
    2023-05-13
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Nguyen, Christine H.;Yan, Dawei;Nambara, Eiji
  • 通讯作者:
    Nambara, Eiji

Nambara, Eiji的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Nambara, Eiji', 18)}}的其他基金

Elucidating regulatory mechanisms for the expression of an Arabidopsis abscisic acid 8'-hydroxylase gene in response to environmental signals
阐明拟南芥脱落酸 8-羟化酶基因响应环境信号表达的调控机制
  • 批准号:
    RGPIN-2019-04144
  • 财政年份:
    2022
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating regulatory mechanisms for the expression of an Arabidopsis abscisic acid 8'-hydroxylase gene in response to environmental signals
阐明拟南芥脱落酸 8-羟化酶基因响应环境信号表达的调控机制
  • 批准号:
    RGPIN-2019-04144
  • 财政年份:
    2021
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating regulatory mechanisms for the expression of an Arabidopsis abscisic acid 8'-hydroxylase gene in response to environmental signals
阐明拟南芥脱落酸 8-羟化酶基因响应环境信号表达的调控机制
  • 批准号:
    RGPIN-2019-04144
  • 财政年份:
    2020
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating regulatory mechanisms for the expression of an Arabidopsis abscisic acid 8'-hydroxylase gene in response to environmental signals
阐明拟南芥脱落酸 8-羟化酶基因响应环境信号表达的调控机制
  • 批准号:
    RGPIN-2019-04144
  • 财政年份:
    2019
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating molecular mechanisms by which seeds respond to environmental factors
阐明种子响应环境因素的分子机制
  • 批准号:
    RGPIN-2014-03621
  • 财政年份:
    2018
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating molecular mechanisms by which seeds respond to environmental factors
阐明种子响应环境因素的分子机制
  • 批准号:
    RGPIN-2014-03621
  • 财政年份:
    2017
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating molecular mechanisms by which seeds respond to environmental factors
阐明种子响应环境因素的分子机制
  • 批准号:
    RGPIN-2014-03621
  • 财政年份:
    2015
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating molecular mechanisms by which seeds respond to environmental factors
阐明种子响应环境因素的分子机制
  • 批准号:
    RGPIN-2014-03621
  • 财政年份:
    2014
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating molecular mechanisms by which seeds respond to environmental factors
阐明种子响应环境因素的分子机制
  • 批准号:
    355784-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual
Elucidating the machanisms by which control abscisic acid levels in plants
阐明控制植物脱落酸水平的机制
  • 批准号:
    355784-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Discovery Grants Program - Individual

相似国自然基金

配子生成素GGN不同位点突变损伤分子伴侣BIP及HSP90B1功能导致精子形成障碍的发病机理
  • 批准号:
    82371616
  • 批准年份:
    2023
  • 资助金额:
    49.00 万元
  • 项目类别:
    面上项目
MYRF/SLC7A11调控施万细胞铁死亡在三叉神经痛脱髓鞘病变中的作用和分子机制研究
  • 批准号:
    82370981
  • 批准年份:
    2023
  • 资助金额:
    48.00 万元
  • 项目类别:
    面上项目
PET/MR多模态分子影像在阿尔茨海默病炎症机制中的研究
  • 批准号:
    82372073
  • 批准年份:
    2023
  • 资助金额:
    48.00 万元
  • 项目类别:
    面上项目
GREB1突变介导雌激素受体信号通路导致深部浸润型子宫内膜异位症的分子遗传机制研究
  • 批准号:
    82371652
  • 批准年份:
    2023
  • 资助金额:
    45.00 万元
  • 项目类别:
    面上项目
靶向PARylation介导的DNA损伤修复途径在恶性肿瘤治疗中的作用与分子机制研究
  • 批准号:
    82373145
  • 批准年份:
    2023
  • 资助金额:
    49.00 万元
  • 项目类别:
    面上项目
O6-methyl-dGTP抑制胶质母细胞瘤的作用及分子机制研究
  • 批准号:
    82304565
  • 批准年份:
    2023
  • 资助金额:
    30.00 万元
  • 项目类别:
    青年科学基金项目
OBSL1功能缺失导致多指(趾)畸形的分子机制及其临床诊断价值
  • 批准号:
    82372328
  • 批准年份:
    2023
  • 资助金额:
    49.00 万元
  • 项目类别:
    面上项目
Irisin通过整合素调控黄河鲤肌纤维发育的分子机制研究
  • 批准号:
    32303019
  • 批准年份:
    2023
  • 资助金额:
    30.00 万元
  • 项目类别:
    青年科学基金项目
转录因子LEF1低表达抑制HMGB1致子宫腺肌病患者子宫内膜容受性低下的分子机制
  • 批准号:
    82371704
  • 批准年份:
    2023
  • 资助金额:
    49.00 万元
  • 项目类别:
    面上项目
上皮细胞黏着结构半桥粒在热激保护中的作用机制研究
  • 批准号:
    31900545
  • 批准年份:
    2019
  • 资助金额:
    24.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Elucidating molecular mechanisms of the water-induced swallowing reflex under non-thirsty and thirsty conditions: the importance of TRPV4
阐明非口渴和口渴条件下水诱导吞咽反射的分子机制:TRPV4的重要性
  • 批准号:
    24K12880
  • 财政年份:
    2024
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidating the Molecular Mechanisms Underlying Sex-Specific Regulation of Energy Metabolism through NUCB1 in Drosophila melanogaster
阐明黑腹果蝇中通过 NUCB1 进行能量代谢的性别特异性调节的分子机制
  • 批准号:
    490373
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Operating Grants
Elucidating Mechanisms of Therapy-Resistance to Interferon-alfa in Myeloproliferative Neoplasm Stem Cells
阐明骨髓增殖性肿瘤干细胞对干扰素-α的治疗耐药机制
  • 批准号:
    10736872
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating and harnessing the molecular mechanisms of protective clearance in endogenous and engineered phagocytes
阐明和利用内源性和工程化吞噬细胞保护性清除的分子机制
  • 批准号:
    10729935
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating causal mechanisms of ethanol-induced analgesia in BXD recombinant inbred mouse lines
阐明 BXD 重组近交系小鼠乙醇诱导镇痛的因果机制
  • 批准号:
    10825737
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating mechanisms of cellular communication critical for head and neck cancer progression and metastasis.
阐明对头颈癌进展和转移至关重要的细胞通讯机制。
  • 批准号:
    10752228
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating the Molecular Mechanisms of Action and Resistance of Microbes to Antibiofilm Lactam Technology
阐明微生物对抗菌膜内酰胺技术的作用和耐药性的分子机制
  • 批准号:
    BB/Y512710/1
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
    Training Grant
Elucidating Molecular Mechanisms Underlying Cooperation in Animal-Bacterial Symbioses
阐明动物-细菌共生合作的分子机制
  • 批准号:
    10711795
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating the functional mechanism of NLRP3 inflammasome activation
阐明NLRP3炎症小体激活的功能机制
  • 批准号:
    10720435
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
Elucidating the mechanisms by which ectopically expressed genes and piRNAs perturb somatic cell function when histone methylation is inappropriately regulated
阐明组蛋白甲基化调节不当时异位表达基因和 piRNA 扰乱体细胞功能的机制
  • 批准号:
    10730632
  • 财政年份:
    2023
  • 资助金额:
    $ 2.48万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了