The Bioinorganic and Bioorganometallic Chemistry of Radionuclides and Boron Clusters
放射性核素和硼簇的生物无机和生物有机金属化学
基本信息
- 批准号:RGPIN-2014-04071
- 负责人:
- 金额:$ 4.95万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Molecular imaging (MI) is revolutionizing diagnostic medicine, drug discovery and basic disease research by making it possible to visualize biological processes non-invasively. MI involves an imaging modality and specially designed chemical probes that bind to and reveal specific biological targets. The use of optical, nuclear and other classes of MI probes is changing how diseases are diagnosed, drugs are developed, and is radically altering how scientists study existing and emerging biochemical systems.
The Valliant group focuses on research that facilitates and expedites the discovery and preparation of novel MI probes. This is achieved by studying the chemistry of medical isotopes and boron compounds including how the latter interacts with radioactive elements used in medical imaging. Recent work involved creating new molecules that can bind medical isotopes such as technetium, which is used extensively in nuclear medicine, in a way that the resulting compounds can be made to selectively target sites of disease.
The next phase of the program builds on our past discoveries to address important research questions focusing on two main areas. The first looks to add to the current understanding of boron chemistry and to use the arising knowledge to develop new kinds of MI probes. The work is based on our recent unearthing of a new way to prepare carboranes in high yield at low temperatures. Carboranes can be used to generate a unique class of compounds (metallocarboranes) in water under conditions that can be used to prepare a new generation of MI probes. New ways to make this particular class of compounds has significant added value in that carboranes are also being used to develop new materials, catalysts and inorganic pharmaceuticals.
The second area involves the creation of compounds that can be used to develop luminescent and radioactive compounds having identical structures (also known as isostructural MI probes). The goal is to use the arising chemistry to create probes that make it possible to link cell and tissue imaging with whole body imaging methods thereby providing connections between understanding of cellular processes and disease detection and characterization in patients. This objective will be achieved by expanding the known chemistry of technetium and rhenium and creating classes of compounds that can be used for both optical and nuclear imaging and that can be directed to bind specific proteins.
The proposed program will leverage the world-class nuclear research facilities at McMaster University, which were recently upgraded in 2010 to include a new suite of radiochemistry laboratories. McMaster is also home to an NSERC Create program in molecular imaging probes (a collaborative training program with the University of Alberta) and the Centre for Probe Development and Commercialization (CPDC) which is a national Centre of Excellence focused on translating new MI probes from the laboratory into clinical trials.
The field of MI relies on probe development and advances in fundamental chemistry such as those described in the application. The outcomes of the proposed research and training program will contribute to the growth of the MI field while addressing the current shortage of highly qualified personnel in a rapidly expanding sector that is an important part of the Canadian economy and healthcare system.
分子成像 (MI) 使非侵入性的生物过程可视化成为可能,正在彻底改变诊断医学、药物发现和基础疾病研究。 MI 涉及一种成像方式和专门设计的化学探针,可结合并揭示特定的生物靶标。光学、核和其他类型的 MI 探针的使用正在改变疾病的诊断、药物的开发方式,并从根本上改变科学家研究现有和新兴生化系统的方式。
Valliant 团队专注于促进和加速新型 MI 探针的发现和制备的研究。这是通过研究医用同位素和硼化合物的化学性质(包括后者如何与医学成像中使用的放射性元素相互作用)来实现的。最近的工作涉及创建可以结合医用同位素(例如广泛用于核医学的锝)的新分子,从而可以使所得化合物选择性地靶向疾病部位。
该计划的下一阶段以我们过去的发现为基础,解决重点关注两个主要领域的重要研究问题。第一个目标是增加目前对硼化学的理解,并利用新产生的知识来开发新型 MI 探针。这项工作基于我们最近发现的一种在低温下高产率制备碳硼烷的新方法。在可用于制备新一代 MI 探针的条件下,碳硼烷可用于在水中生成一类独特的化合物(金属碳硼烷)。制造此类特殊化合物的新方法具有显着的附加值,因为碳硼烷也可用于开发新材料、催化剂和无机药物。
第二个领域涉及创建可用于开发具有相同结构的发光和放射性化合物(也称为同构 MI 探针)的化合物。目标是利用新兴的化学方法来创建探针,使细胞和组织成像与全身成像方法联系起来成为可能,从而在细胞过程的理解与患者疾病检测和表征之间提供联系。这一目标将通过扩展锝和铼的已知化学性质并创建可用于光学和核成像并可定向结合特定蛋白质的化合物类别来实现。
拟议的计划将利用麦克马斯特大学世界一流的核研究设施,该设施最近于 2010 年进行了升级,包括一套新的放射化学实验室。麦克马斯特还是 NSERC 创建分子成像探针项目(与阿尔伯塔大学合作的培训项目)和探针开发和商业化中心 (CPDC) 的所在地,CPDC 是一个国家卓越中心,致力于将新的 MI 探针从实验室转化为临床试验。
MI 领域依赖于探针的开发和基础化学的进步,例如申请中描述的那些。拟议的研究和培训计划的成果将有助于 MI 领域的发展,同时解决目前快速扩张的行业高素质人才短缺的问题,该行业是加拿大经济和医疗保健系统的重要组成部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Valliant, John其他文献
Valliant, John的其他文献
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{{ truncateString('Valliant, John', 18)}}的其他基金
CPDC - CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION / Centre de Développement et de Commercialisation de Traceurs
CPDC - 探针开发和商业化中心 / Centre de Développement et de Commercialization de Traceurs
- 批准号:
515192-2017 - 财政年份:2020
- 资助金额:
$ 4.95万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
CPDC - CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION / Centre de Développement et de Commercialisation de Traceurs
CPDC - 探针开发和商业化中心 / Centre de Développement et de Commercialization de Traceurs
- 批准号:
515192-2017 - 财政年份:2019
- 资助金额:
$ 4.95万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
The Bioinorganic and Bioorganometallic Chemistry of Radionuclides and Boron Clusters
放射性核素和硼簇的生物无机和生物有机金属化学
- 批准号:
RGPIN-2014-04071 - 财政年份:2018
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
CPDC - CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION / Centre de Développement et de Commercialisation de Traceurs
CPDC - 探针开发和商业化中心 / Centre de Développement et de Commercialization de Traceurs
- 批准号:
515192-2017 - 财政年份:2018
- 资助金额:
$ 4.95万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
CPDC - CENTRE FOR PROBE DEVELOPMENT AND COMMERCIALIZATION / Centre de Développement et de Commercialisation de Traceurs
CPDC - 探针开发和商业化中心 / Centre de Développement et de Commercialization de Traceurs
- 批准号:
515192-2017 - 财政年份:2017
- 资助金额:
$ 4.95万 - 项目类别:
Centres of Excellence for Commercialization and Research - Group
Development of Molecularly Targeted Ultrasound Contrast Agents for Prostate Cancer Imaging using Bioorthogonal Chemistry
利用生物正交化学开发用于前列腺癌成像的分子靶向超声造影剂
- 批准号:
493840-2016 - 财政年份:2017
- 资助金额:
$ 4.95万 - 项目类别:
Collaborative Health Research Projects
Centre for Probe Development and Commercialization (CPDC)
探针开发和商业化中心 (CPDC)
- 批准号:
507530-2017 - 财政年份:2017
- 资助金额:
$ 4.95万 - 项目类别:
Centres of Excellence for Commercialization and Research - Letters of Intent
The Bioinorganic and Bioorganometallic Chemistry of Radionuclides and Boron Clusters
放射性核素和硼簇的生物无机和生物有机金属化学
- 批准号:
RGPIN-2014-04071 - 财政年份:2017
- 资助金额:
$ 4.95万 - 项目类别:
Discovery Grants Program - Individual
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放射性核素和硼簇的生物无机和生物有机金属化学
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