Bacterial effector proteins as tools to study cell biology

细菌效应蛋白作为研究细胞生物学的工具

• 批准号: RGPIN-2014-05119
• 负责人: Gruenheid, Samantha
• 金额: $ 2.99万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=611452
• 关键词: Bacterial; effector; proteins; tools; study

Some bacteria inject proteins into human cells to alter human cell function. By studying how these bacterial proteins work, we can learn new things about how human cells function. Past studies by our group and others of how bacteria alter human cell pathways to move around in cells has revealed new insights into how human cells regulate their shape and structure. In the current proposal, we will extend our studies on a new set of bacterial proteins that alter the delivery of human cell proteins to different sites within the cell. We anticipate that these studies will lead to new insights into these processes.

一些细菌将蛋白质注入人体细胞以改变人体细胞功能。通过研究这些细菌蛋白质如何工作，我们可以了解有关人类细胞功能的新事物。我们小组和其他人过去关于细菌如何改变人类细胞通路以在细胞中移动的研究揭示了人类细胞如何调节其形状和结构的新见解。在目前的提案中，我们将扩展我们对一组新的细菌蛋白质的研究，这些蛋白质改变了人类细胞蛋白质向细胞内不同位点的递送。我们预计，这些研究将导致对这些过程的新见解。