Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
基本信息
- 批准号:RGPIN-2014-06262
- 负责人:
- 金额:$ 1.97万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Diversity in nature is multivariate. Individuals differ from each other in more than one phenotypic trait, where a phenotypic trait is simply a measured physical and/or behavioural attribute of an individual. Differences among individuals and species in their multivariate phenotype determine, in part, differences in the niche they occupy. This idea of a multivariate niche traces back to a classic paper by Hutchinson in 1957. For example the pollination niche of a plant species is a function of its flowering time, flower color, flower symmetry, nectar production, pollen production, and flower number. The evolution of a species’ multivariate niche depends on several factors, including the physical attributes of the area the species occupies, the other species it interacts with and the genotypes of individuals that make up the species. Furthermore, there is evidence that ecosystem processes are determined, in part, by the multivariate phenotypes of species that compose a community.
Using theoretical modeling, my lab studies how the evolutionary history of a species affects its multivariate diversity. We know from previous work that genealogical history can restrict multivariate diversity, but the mechanisms that can overcome this limit are not fully understood. Current work in my lab is exploring genetic mechanisms that can overcome this constraint, with a focus on epistatic gene-action. Epistatic gene-action occurs when mutations interact to produce a phenotype in a non-additive manner. Recent work in my lab studying asexual populations showed that epistatic gene-action reduces the constraint of genealogical structure on multivariate evolution.
In this grant application we seek support to characterize how epistatic gene-action affects multivariate diversity in populations that undergo sexual reproduction and recombination. In addition, we seek to determine whether unique aspects of the meiotic process in polyploid species facilitate the evolution of multivariate diversity.
Recent theoretical work indicates that ecological diversification is easier when it involves a multivariate versus a univariate trait. Here we seek to determine whether epistasis can further facilitate ecological diversification, which may be important for understanding the causes of speciation.
The genealogical approach to modeling epistasis and multivariate trait evolution is technically complicated. As such, direct estimation of parameters in the model is difficult in natural settings. In this grant we seek to develop an indirect approach to estimate attributes of our model that would test whether epistatic gene-action in combination with genealogical structure is, in fact, important with respect to determining diversity in nature.
Lastly, we seek to address the question of how multivariate diversity arises in the first place. Work in developmental biology indicates modular gene-action and gene duplication may facilitate the evolution of diversity. Recent empirical work suggests that gene duplications introduce new epistatic interactions. Here we seek to determine whether gene duplication in combination with epistatic gene-action facilitates the evolution of multivariate diversity.
自然界的多样性是多元的。个体在一个以上的表型特征上彼此不同,其中一个表型特征仅仅是一个人的测量的身体和/或行为属性。个体和物种在其多变量表型上的差异在一定程度上决定了它们所处生态位的差异。这种多元生态位的想法可以追溯到1957年哈钦森的一篇经典论文。例如,一种植物的授粉生态位是其开花时间、花色、花的对称性、花蜜产量、花粉产量和花数的函数。一个物种的多变量生态位的进化取决于几个因素,包括该物种所在地区的物理属性、与其相互作用的其他物种以及组成该物种的个体的基因类型。此外,有证据表明,生态系统过程在一定程度上是由组成群落的物种的多变量表型决定的。
通过理论建模,我的实验室研究了一个物种的进化史如何影响其多元多样性。从以前的工作中我们知道,系谱历史可以限制多变量多样性,但能够克服这一限制的机制还没有完全了解。我实验室目前的工作是探索可以克服这一限制的遗传机制,重点是上位性基因作用。当突变以非加性方式相互作用产生表型时,上位性基因作用就会发生。我的实验室最近对无性群体进行的研究表明,上位性基因作用减少了系谱结构对多变量进化的约束。
在这项赠款申请中,我们寻求支持,以确定上位性基因作用如何影响有性繁殖和重组种群的多变量多样性。此外,我们试图确定多倍体物种减数分裂过程的独特方面是否有助于多变量多样性的进化。
最近的理论工作表明,当生态多样化涉及到多变量而不是单变量特征时,它更容易实现。在这里,我们试图确定上位性是否能进一步促进生态多样性,这对于理解物种形成的原因可能是重要的。
用系谱方法模拟上位性和多变量性状进化在技术上是复杂的。因此,在自然环境中直接估计模型中的参数是困难的。在这项资助中,我们试图开发一种间接的方法来估计我们模型的属性,该方法将测试上位性基因作用与系谱结构相结合是否实际上对于决定自然界的多样性是重要的。
最后,我们寻求解决多元多样性最初是如何产生的问题。发育生物学的研究表明,模块化的基因作用和基因复制可能会促进多样性的进化。最近的实证研究表明,基因复制引入了新的上位性相互作用。在这里,我们试图确定基因复制结合上位性基因作用是否促进了多变量多样性的进化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Griswold, Cortland其他文献
Griswold, Cortland的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Griswold, Cortland', 18)}}的其他基金
Advancing ancestral graph theory of metacommunities and population genetic theory of polyploids
推进元群落祖先图论和多倍体群体遗传理论
- 批准号:
RGPIN-2020-04151 - 财政年份:2022
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing ancestral graph theory of metacommunities and population genetic theory of polyploids
推进元群落祖先图论和多倍体群体遗传理论
- 批准号:
RGPIN-2020-04151 - 财政年份:2021
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing ancestral graph theory of metacommunities and population genetic theory of polyploids
推进元群落祖先图论和多倍体群体遗传理论
- 批准号:
RGPIN-2020-04151 - 财政年份:2020
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2018
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2017
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2014
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Theoretical models of the evolutionary genetics of adaptation
适应进化遗传学的理论模型
- 批准号:
371772-2009 - 财政年份:2013
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Theoretical models of the evolutionary genetics of adaptation
适应进化遗传学的理论模型
- 批准号:
371772-2009 - 财政年份:2012
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Theoretical models of the evolutionary genetics of adaptation
适应进化遗传学的理论模型
- 批准号:
371772-2009 - 财政年份:2011
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
Surface sensing, memory, and motility control in biofilm formation
生物膜形成中的表面传感、记忆和运动控制
- 批准号:
10317069 - 财政年份:2019
- 资助金额:
$ 1.97万 - 项目类别:
Surface sensing, memory, and motility control in biofilm formation
生物膜形成中的表面传感、记忆和运动控制
- 批准号:
10080709 - 财政年份:2019
- 资助金额:
$ 1.97万 - 项目类别:
Surface sensing, memory, and motility control in biofilm formation
生物膜形成中的表面传感、记忆和运动控制
- 批准号:
10546429 - 财政年份:2019
- 资助金额:
$ 1.97万 - 项目类别:
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2018
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2017
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2015
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
Mapping the Intersection: Self-identification and Genetic Ancestry
绘制交叉点:自我认同和遗传祖先
- 批准号:
8768334 - 财政年份:2014
- 资助金额:
$ 1.97万 - 项目类别:
Advancing a genealogical and systems-based theory of the evolution of biodiversity
推进生物多样性演化的谱系学和系统理论
- 批准号:
RGPIN-2014-06262 - 财政年份:2014
- 资助金额:
$ 1.97万 - 项目类别:
Discovery Grants Program - Individual
STATISITICAL DESIGN, MONITORING & COORD. OF VISION CLINICAL TRIALS & EPIDEMIOLOGY
统计设计、监测
- 批准号:
8564678 - 财政年份:2011
- 资助金额:
$ 1.97万 - 项目类别:
STATISITICAL DESIGN, MONITORING & COORD. OF VISION CLINICAL TRIALS & EPIDEMIOLOGY
统计设计、监测
- 批准号:
8602373 - 财政年份:2011
- 资助金额:
$ 1.97万 - 项目类别: