Evolution of immunoregulatory networks: preventing autoimmunity at the expense of perpetuating chronicity in persistent infections

免疫调节网络的进化：以持续感染的慢性化为代价来预防自身免疫

• 批准号: DP110101351
• 负责人: Dr Marc Pellegrini
• 金额: --
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2011-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101351
• 关键词: Evolution; immunoregulatory; networks; preventing; autoimmunity

Chronic pathogens like HIV take advantage of human genes that regulate immune responses, which evolved to prevent autoimmunity, enabling them to evade eradication. This project defines the nature and interplays between these genes and will provide valuable clues as to how immunity can be manipulated to promote clearance of persistent infections.

像HIV这样的慢性病原体利用了人类调节免疫反应的基因，这种基因进化为防止自身免疫，使它们能够逃避根除。该项目定义了这些基因之间的性质和相互作用，并将为如何操纵免疫以促进清除持续感染提供有价值的线索。