Immunoregulatory Networks

描述（由申请人提供）：本提案请求支持Dario A.A.组织的名为免疫调节网络的Keystone研讨会会议。作者：Steven F.齐格勒和希尔德切鲁特尔，将于2011年4月1日至6日在科罗拉多布雷肯里奇举行。免疫调节网络在预防自身免疫和其他炎性疾病中起着关键作用，但也限制抗肿瘤免疫并调节对病原体的免疫应答。虽然调节性T细胞（Tcells）是该网络的核心组成部分，但还有许多其他细胞群和分子途径有助于这些网络。关于免疫调节网络的Keystone研讨会将重点关注不同的细胞和分子组分如何整合和合作，以预防自身免疫和控制炎症免疫反应。本次会议将剖析我们目前对四个关键领域的理解：调节细胞发育和稳态的转录控制，免疫调节网络的分子控制，调节功能的机制和调节T细胞的可塑性。我们的目的还在于讨论Tclase如何与不同的细胞类型相互作用，或利用不同的细胞因子来调节或间接介导其活性。最后，我们将评估如何利用所提出的进展来开发针对自身免疫性疾病、炎症性疾病、慢性感染和癌症的新疗法。 公共卫生相关性：免疫系统是分子和细胞的复杂集合体，它们同步工作以微调对病原体的反应并调节疾病状态。这些基本的生物过程是由“免疫调节网络”介导的，这是一个同样复杂的相互作用、制衡网络。关于免疫调节网络的Keystone研讨会将重点关注不同的细胞和分子组分如何整合和合作，以预防自身免疫和控制炎症免疫反应。

DESCRIPTION (provided by applicant): This proposal requests support for a Keystone Symposia meeting entitled Immunoregulatory Networks, organized by Dario A.A. Vignali, Steven F. Ziegler and Hilde Cheroutre, which will be held in Breckenridge, Colorado from April 1 - 6, 2011. Immunoregulatory networks play a pivotal role in preventing autoimmunity and other inflammatory diseases, but also restrict anti-tumor immunity and modulate immune responses to pathogens. While regulatory T cells (Tregs) are a central component of this network, there are many other cell populations and molecular pathways that contribute to these networks. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses. This meeting will dissect our current understanding of four key areas: transcriptional control of regulatory cell development and homeostasis, molecular control of immunoregulatory networks, mechanisms of regulatory function, and regulatory T cell plasticity. We also aim to discuss how Tregs interact with different cell types or utilize different cytokines that modulate or indirectly mediate their activity. Finally, we will assess how the advances presented can be utilized to develop novel therapies for autoimmune diseases, inflammatory diseases, chronic infections and cancers. PUBLIC HEALTH RELEVANCE: The immune system is a complex conglomeration of molecules and cells that work synchronously to fine tune responses to pathogens and modulate disease states. These fundamental biological processes are mediated by "immunoregulatory networks", an equally complex network of interactions, checks and balances. The Keystone Symposia meeting on Immunoregulatory Networks will focus on how different cellular and molecular components integrate and cooperate to prevent autoimmunity and control inflammatory immune responses.