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Determining the role of histone modifications in mediating transcriptional consistency in beta-cells and in diabetes pathogenesis

Determining the role of histone modifications in mediating transcriptional consistency in beta-cells and in diabetes pathogenesis
确定组蛋白修饰在介导 β 细胞转录一致性和糖尿病发病机制中的作用
批准号：
355767
负责人：
Hoffman Brad G
金额：
$54.89万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-10-01 至 2021-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=355767&lang=en
关键词：
Beta-Cell Chromatin Structure Diabetes Histone Modifications Transcriptional Regulation Trithorax Complex

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英文摘要
During the development of type 2 diabetes immune cell induced inflammation and metabolic stress induce insulin secreting beta-cells to lose their normal functionality. In part this is because the beta-cells have reduced levels or critical genes that help
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