Examining nociception with a laser evoked potential stimulator

激光发射的辐射热是客观测量伤害性诱发电位的金标准方法。该应用程序的中心目标是支持购买用于在不列颠哥伦比亚大学（UBC）获得诱发电位的激光器。这一关键设备对UBC实验室的定位至关重要(克莱默博士，申请人和共同申请人。Ramer， Blouin和Dumont)是痛觉研究的领导者。激光器建立在现有的核心基础设施（例如，其他刺激器和记录设备）上，将是UBC的第一个此类设备，并应用于人类和动物研究。激光的结合扩展了NSERC发现资助（DG）博士的框架。Kramer, Ramer， Blouin和Dumont通过为每个调查员创造新的关键调查线。Kramer博士将特别利用激光刺激器结合局部辣椒素的应用来研究人类继发性痛觉过敏区域的感觉。雷默博士将开发激光诱发电位的应用，作为啮齿动物伤害感觉的客观替代测量。最后，Blouin博士将利用激光研究评估前庭刺激对伤害感觉的调节。所有三条调查线都高度依赖于激光刺激器的购买，原因与接触热的限制有关（即，不是纯粹有害的和大的刺激区域）。激光还将用于支持正在进行的工作，以改善使用音频信号转换技术获取脑电图（Guy Dumont博士，正在等待NSERC -与Kramer博士的合作健康研究申请）。除了研究应用的迫切需要外，UBC的激光将为使用国际公认的金标准仪器培训高素质人才提供令人兴奋的机会，并增加国家合作的前景（例如，拉瓦尔大学）。

Radiant heat emitted from a laser is the gold-standard method for the objective measurement of nociceptive evoked potentials. The central aim of this application is to support the purchase of a laser for the acquisition of evoked potentials at the University of British Columbia (UBC). This key piece of equipment is essential to position laboratories at the UBC (Dr. Kramer, applicant and co-applicants Drs. Ramer, Blouin, and Dumont) as leaders in in the study of nociception. A laser builds on existing core infrastructure (e.g., other stimulators and recording equipment), will be the first of its kind at UBC, and applied in both humans and animal research studies. The incorporation of a laser expands the NSERC Discovery Grant (DG) framework of Drs. Kramer, Ramer, Blouin, and Dumont by creating new and pivotal lines of investigation for each investigator. Dr. Kramer will specifically utilize the laser stimulator in conjunction with the application of topical capsaicin to investigate sensation in the area of secondary hyperalgesia in humans. Dr. Ramer will develop the application of laser evoked potentials as an objective surrogate measure of nociception in rodents. Finally, Dr. Blouin will employ the laser in studies assessing the modulation of nociception with vestibular stimulation. All three lines of investigation are highly dependent on the purchase of a laser stimulator for reasons related to limitations of contact heat (i.e., not purely noxious and large stimulation area). The laser will also be used to support ongoing work to improve the acquisition of electroencephalography using audio signal conversion technology (Dr. Guy Dumont, pending NSERC - Collaborative Health Research application with Dr. Kramer). In addition to the urgent need for research applications, a laser at UBC will provide an exciting opportunity for training of highly qualified personnel using an internationally regarded gold standard instrument and increase prospects for national collaborations (e.g., University of Laval).