The role of microbial sphingolipids in the initiation, progression and treatment of inflammatory bowel disease

微生物鞘脂在炎症性肠病的发生、进展和治疗中的作用

• 批准号: 362243
• 负责人: Brown Eric
• 金额: $ 10.93万
• 依托单位: Broad Institute of MIT and Harvard (Cambridge, MA)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-11-01 至 2019-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=362243&lang=en
• 关键词: Cell Signalling; Genomics; Inflammation; Inflammatory Bowel Disease; Intestinal Microbiome; Microbiology; Mucosal Immunology; Sphingolipids

A healthy mammalian gastrointestinal tract is shaped by a co-evolution between the immune system and molecules derived from our resident gut microbes, the gut microbiome. Despite the wide array of mechanisms working to promote intestinal homeostasis, brea

健康的哺乳动物胃肠道是由免疫系统和来自我们常驻肠道微生物（肠道微生物组）的分子共同进化形成的。尽管有各种各样的机制来促进肠道内稳态，但断裂