Developing and validating a wearable device to assess cardiac function during sleep

该提案描述了基于心音分析的信号处理算法的开发和验证，以检测高血压、中风和心脏病等心血管疾病的风险和症状。通过与BresoTec Inc.的密切合作，这项工作将改善睡眠期间呼吸障碍及其心血管后果的管理。特别是，该项目将开发强大的算法来检测心率，血压和心脏功能。所提出的算法可用于远程监测心脏功能和诊断心血管疾病的风险时，病人在家里，如在睡眠中，或在日常activity.The工作计划涉及两个项目，将解决两个目标的项目。第一个目标是在睡眠期间以高精度检测心音，并从将同时记录的其他声音（例如呼吸声、打鼾和环境噪声）中提取心音。第二个目标将集中于开发模型和信号处理算法，以从提取的心音中估计心脏功能参数。这两个项目都是基于我们最近开发的用于分析呼吸和心音的算法，这两个项目都将使行业受益匪浅。BresoTec Inc.通过现金和实物捐助大力支持这一项目。BresoTec公司在过去三年中与该研究小组建立了合作记录。BresoTec公司具有独特的优势，可以利用拟议研究计划的研究和HQP成果。

This proposal describes the development and validation of signal processing algorithms based on heart sound analysis to detect the risk and symptoms of cardiovascular disorders such as hypertension, stroke, and heart disease. In a close collaboration with BresoTec Inc, this work will improve management of breathing disorders during sleep and their cardiovascular consequences. In particular, this project will develop robust algorithms to detect heart rate, blood pressure, and cardiac function. The proposed algorithms can be used for tele-monitoring of cardiac function and diagnosing the risk of cardiovascular disorders when the patients are at home, such as during sleep, or during everyday activities.The workplan involves two projects that will address two objectives of the project. The first objective is to detect heart sounds with high accuracy during sleep and to extract them from other sounds that will be recorded simultaneously, such as breathing sounds, snoring and ambient noise. The second objective will focus on developing models and signal processing algorithms to estimate cardiac function parameters from the extracted heart sounds. Both projects are based on the algorithms that we have developed recently for analyzing respiratory and heart sounds, and both will uniquely benefit the industry.BresoTec Inc is strongly supporting this project through both cash and in-kind contribution. BresoTec Inc has established a track record of collaboration with the research group in the past three years. BresoTec Inc is uniquely positioned to leverage the research and HQP outputs of the proposed research program.