Mass spec studio software for the pharmaceutical market - a phase one project

适用于制药市场的质谱工作室软件 - 第一阶段项目

• 批准号: 508445-2017
• 负责人: Schriemer, David
• 金额: $ 9.11万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=618930
• 关键词: Mass; spec; studio; software; pharmaceutical

Imagine spending hundreds of thousands of dollars on powerful new technology for life science research, onlyto discover that you cannot fully use the data that it produces. This is a situation in a large number of academicand industry laboratories that have purchased mass spectrometers for R&D spanning all areas of biological andenvironmental sciences. New technologies in mass spectrometry have spurred tremendous growth in newmethods for compound characterization, especially in the biopharmaceuticals industry. Biopharmaceuticals areprotein drugs. They represent a very effective class of pharmaceutical agents and the area is experiencing ahigh rate of growth worldwide. Mass spectrometry is the perfect choice of technology to support thedevelopment of new protein drugs, and to ensure that these complicated drugs are safe to use. The companiesthat make mass spectrometers are not able to keep up with the many new directions that biopharmaceuticalcompanies are taking mass spectrometry, and the situation is expected to deteriorate further. We developed atransformative solution to this problem, in the form of an application-building software platform called theMass Spec Studio. This platform strongly reduces the development time for creating new applications. It iscurrently houses research-grade plug-ins that are very useful for a form of protein characterization calledhigher-order structure (HOS) analysis. In this project we will complete version 2 of the Mass Spec Studio. Itwill contain industry-leading plug-ins for HOS analysis and streamline the application development processeven further. The goal of the project is to create a package of technologies that will help mass spectrometrykeep pace with the needs of the biopharmaceutical industry, and ensure that protein drugs are effective andsafe.

想象一下，花费数十万美元用于生命科学研究的强大新技术，却发现你无法充分利用它产生的数据。这是一个情况，在大量的学术和工业实验室购买了质谱仪的研发跨越所有领域的生物和精神科学。质谱分析的新技术促进了化合物表征新方法的巨大发展，特别是在生物制药行业。生物药物是蛋白质药物。它们代表了一类非常有效的药剂，该领域在全球范围内正经历着高速增长。质谱技术是支持新蛋白质药物开发和确保这些复杂药物安全使用的最佳技术选择。制造质谱仪的公司无法跟上生物制药公司采用质谱仪的许多新方向，预计情况将进一步恶化。我们开发了一个针对这个问题的转化解决方案，以一个名为Mass Spec Studio的应用程序构建软件平台的形式。该平台大大缩短了创建新应用程序的开发时间。它目前拥有研究级插件，这些插件对于一种称为高阶结构（HOS）分析的蛋白质表征形式非常有用。在这个项目中，我们将完成质谱工作室的第2版。iData包含行业领先的HOS分析插件，并进一步简化应用程序开发流程。该项目的目标是创建一套技术，帮助质谱仪跟上生物制药行业的需求，并确保蛋白质药物有效和安全。