Sustainable, continuous chemical manufacturing using micro flow reactor technology

使用微流反应器技术进行可持续、连续的化学制造

• 批准号: 445703-2012
• 负责人: Organ, Michael
• 金额: $ 25.58万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619397
• 关键词: Sustainable; continuous; chemical; manufacturing; using

Many business sectors have moved production to a 'just-in-time' operation that offers many practicaladvantages that lead to improved efficiency and cost savings. Fine-chemical synthesis, such as the preparationof drugs, may have the most to be gained by moving to such a format and yet chemical manufacturingcontinues to be done following traditional scale-up strategies with the goal of producing single batches of largequantities of final material. The build up and maintenance of large chemical inventories is a serious potentialhealth and environmental concern and creates logistical and quality control issues. For such approaches to beadopted, it would take a significant shift in mind set in industry and the invention of pioneering newtechnology. Flowed chemical synthesis is currently being evaluated as the technological platform upon whichsustained chemical manufacturing will be built. The premise is that reactions can be performed on a small scaleat any one point in time in small diameter reactors (chips or tubes). This will allow for rapid reaction conditionassessment and optimization literally on single drops of effluent from the reactor, thus drastically reducingenvironmental impact. Once optimized conditions are achieved, the process can be run for as long as isnecessary to generate the desired amount of material. If much larger quantities are required, the reactions canbe flowed in parallel, but again it is produced now only in the quantities necessary to meet need eliminatinglarge-scale chemical storage. The PI of this initiative has developed pioneering flow technology usingmicrowave irradiation to rapidly drive reactions to completion in the relatively short time that they reside in theflow reactor. He has assembled a diverse team of chemical, computer, and electronics engineers and syntheticand analytical chemists to integrate the flow microwave reactor into a standalone synthesis plant capable ofreaction optimization using artificial intelligence with complete computer control. This new technology, whichcan operate at very high temperatures and pressures as is necessary, will provide a conceptually uniqueapproach to chemical synthesis and a solution for sustained chemical manufacturing in Canada and beyond.

许多商业部门已经将生产转移到“即时”操作，这提供了许多实际优势，从而提高了效率并节省了成本。精细化学合成，如药物的纯化，可能通过转向这种形式获得最大收益，但化学制造继续遵循传统的规模扩大战略，目标是生产单批大量的最终材料。建立和维持大量化学品库存是一个严重的潜在健康和环境问题，并造成后勤和质量控制问题。要采用这种方法，需要工业界的思维方式发生重大转变，并发明开创性的新技术。流动化学合成目前正被评估为可持续化学制造的技术平台。前提是反应可以在小直径反应器（芯片或管）中的任何一个时间点上以小规模进行。这将允许快速反应条件评估和优化字面上的单滴流出物从反应器，从而大大减少环境影响。一旦达到优化的条件，该过程可以运行只要是必要的，以产生所需的材料量。如果需要更大的量，反应可以平行进行，但是现在生产的量也只能满足需要，从而消除了大规模的化学品储存。该倡议的PI已经开发出先进的流动技术，使用微波辐射快速驱动反应在相对较短的时间内完成，它们驻留在流动反应器中。他组建了一支由化学、计算机和电子工程师以及合成和分析化学家组成的多元化团队，将流动微波反应器集成到一个独立的合成工厂中，该工厂能够使用人工智能进行反应优化，并具有完整的计算机控制。这项新技术可以在必要的高温和高压下运行，将为化学合成提供一种概念上独特的方法，并为加拿大及其他地区的持续化学制造提供解决方案。