Cellular-based Mechanisms Underlying Oscillatory Brain Dynamics

振荡脑动力学的细胞机制

• 批准号: RGPIN-2016-06182
• 负责人: Skinner, Frances
• 金额: $ 4.66万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628819
• 关键词: Cellular; based; Mechanisms; Underlying; Oscillatory

How does the brain work? Rhythmic brain activities are a common feature in brain recordings and there is now much evidence indicating that the generation of these rhythms in our brain circuits is a way in which our brains work to organize information. However, it is far from clear how these rhythms are generated. The complex networks of the brain are a challenge to appreciate because of the multi-scale nature of the brain along with its myriad of biological details. Mathematical models are strongly needed to help us tackle this complexity, but experimental interactions with our models need to be clear if we are to achieve an understanding of the biological system, and not only the mathematical model system. The long-term goal of my lab is to determine cellular-based mechanisms underlying oscillatory network dynamics, and we do this by combining theory, experiment and modeling at initial stages of the research. It is important to note that determining a cellular-based understanding is critical as we know that cell specifics matter.

大脑如何运作？有节奏的大脑活动是大脑记录中的一个常见特征，现在有很多证据表明，我们大脑回路中这些节律的产生是我们的大脑组织信息的一种方式。然而，这些节奏是如何产生的还不清楚。由于大脑的多尺度性质及其无数的生物细节，理解大脑的复杂网络是一个挑战。强烈需要数学模型来帮助我们解决这种复杂性，但如果我们要了解生物系统而不仅仅是数学模型系统，就需要清楚与模型的实验相互作用。我实验室的长期目标是确定振荡网络动力学的细胞机制，我们在研究的初始阶段通过结合理论、实验和建模来实现这一目标。值得注意的是，确定基于细胞的理解至关重要，因为我们知道细胞特性很重要。