Role of Binding Determinants in Enzyme Catalysis

结合决定因素在酶催化中的作用

• 批准号: RGPIN-2016-05083
• 负责人: Bearne, Stephen
• 金额: $ 2.77万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628852
• 关键词: Role; Binding; Determinants; Enzyme; Catalysis

Enzymes are proteins that accelerate (catalyze) biological reactions. My research focuses on understanding how catalysis arises from the interactions that occur between enzymes and the substrates they act on. This knowledge is essential to understand how enzymes work, to engineer new enzyme catalysts, and to design enzyme inhibitors (drugs/herbicides). Primarily, I study mandelate racemase (

酶是加速（催化）生物反应的蛋白质。我的研究重点是了解催化是如何从酶和它们作用的底物之间发生的相互作用中产生的。这些知识对于了解酶如何工作，设计新的酶催化剂和设计酶抑制剂（药物/除草剂）至关重要。首先，我研究扁桃酸消旋酶（