Integrating genomics, development and evolution to elucidate the genotype-phenotype map of Drosophila wing morphology

整合基因组学、发育和进化来阐明果蝇翅膀形态的基因型-表型图

• 批准号: RGPIN-2016-06453
• 负责人: Dworkin, Ian
• 金额: $ 5.46万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628920
• 关键词: Integrating; genomics; development; evolution; elucidate

My long term research goal is to understand the genetic, genomic and developmental basis of natural phenotypic variation. Specifically, the goal of providing a broader quantitative genetics framework for precise and long-term predictions of phenotypic change critically requires a more integrative and detailed understanding of how genetic and environmental variation modulates development. Research in my lab works to address critical issues regarding the function of natural genetic variants across wild type genetic backgrounds, and how this ultimately shapes phenotypic effects. Our work is at the interface of developmental and quantitative genomics using a genetic model organism (

我的长期研究目标是了解自然表型变异的遗传、基因组和发育基础。具体地说，为精确和长期预测表型变化提供更广泛的数量遗传学框架的目标，关键是需要对遗传和环境变异如何调节发育有更全面和详细的理解。我实验室的研究致力于解决有关野生型遗传背景中自然遗传变异的功能以及这最终如何形成表型效应的关键问题。我们的工作是在发育和数量基因组学的交界处使用遗传模式生物(