An integrative approach to elucidating the genotype-phenotype map of Drosophila wing shape and form.

阐明果蝇翅膀形状和形态的基因型-表型图谱的综合方法。

• 批准号: RGPIN-2015-04031
• 负责人: Dworkin, Ian
• 金额: $ 2.48万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589550
• 关键词: integrative; approach; elucidating; genotype; phenotype

Understanding the genetic and developmental mechanisms by which a mutation influences phenotypes remains an outstanding problem in biology. Significant progress has been made, yet it is unclear whether such findings extend to natural variants of smaller magnitude that segregate in mixed genetic backgrounds and influence "complex" traits. In particular the degree to which segregating alleles in the same (developmental genes) have similar effects in natural populations is generally unknown. Thus there is a critical need to not only identify, but to developmentally characterize and compare the mutational effects of natural variants relative to induced mutational effects.

了解突变影响表型的遗传和发育机制仍然是生物学中的一个突出问题。已经取得了重大进展，但目前还不清楚这些发现是否延伸到较小规模的自然变异，分离在混合遗传背景和影响“复杂”的性状。特别是，在自然种群中，相同（发育基因）中分离等位基因的程度通常是未知的。因此，迫切需要不仅鉴定，而且在发育上表征和比较天然变体相对于诱导突变效应的突变效应。