Functional characterization of proteins associated with promeylocytic leukemia nuclear bodies

早幼粒细胞白血病核体相关蛋白的功能表征

• 批准号: RGPIN-2016-05110
• 负责人: Zhu, XuDong
• 金额: $ 2.26万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628979
• 关键词: Functional; characterization; proteins; associated; promeylocytic

The vast majority of the genetic material of the eukaryotic cell resides in the nucleus, which is a highly compartmentalized organelle. Within the nucleus are a variety of subnuclear compartments that do not necessarily harbour the genetic material but serve as important centers for regulating a variety of nuclear processes involving the genetic material. One of these subnuclear compartments is known as promyelocytic leukemia (PML) nuclear bodies, which play an important role in the regulation of induction of apoptosis and cellular senescence, inhibition of proliferation, maintenance of genomic stability and the antiviral response. Over 100 proteins have been found to reside, permanently or transiently, in PML bodies, however, the nature of their association with this organelle, their interactions with one another, and how they contribute to the regulation of various cellular processes remains largely uncharacterized. The

真核细胞的绝大多数遗传物质存在于细胞核中，这是一个高度区隔的细胞器。在细胞核内有各种亚核隔间，它们不一定藏匿遗传物质，但充当调节涉及遗传物质的各种核过程的重要中心。其中一个亚核室称为早幼粒细胞白血病(PML)核体，它在诱导细胞凋亡和细胞衰老、抑制增殖、维持基因组稳定和抗病毒反应中发挥着重要作用。超过100种蛋白质被发现永久或短暂地存在于PML小体中，然而，它们与这个细胞器的结合的性质，它们彼此之间的相互作用，以及它们如何参与调节各种细胞过程，在很大程度上仍不清楚。这个