Zebrafish epiboly as a model of vertebrate embryonic cell rearrangement

斑马鱼表皮作为脊椎动物胚胎细胞重排的模型

• 批准号: 283229-2010
• 负责人: Bruce, Ashley
• 金额: $ 4.08万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629033
• 关键词: Zebrafish; epiboly; model; vertebrate; embryonic

A major question in developmental biology is how cell movements are coordinated to give rise to adult forms, which is integral to the development of an animal from a fertilized egg into a complex adult. In vertebrate embryos, the movement of cells within coherent cell masses plays a prominent role in development, though the mechanisms by which cells move across each other are poorly understood. We study these mechanisms in a simple, experimentally tractable model, the zebrafish. Through our work, we will learn about fundamental cellular properties and mechanisms that control cell movements that are likely to be widely used throughout animal development. This knowledge may ultimately be useful in understanding disease states that result from aberrant cell movements during development or even those occurring later in life, such as metastatic cancer.

发育生物学中的一个主要问题是，细胞运动如何协调才能形成成体，这是动物从受精卵发育成复杂成体所不可或缺的。在脊椎动物胚胎中，细胞在连贯的细胞团中的运动在发育中起着突出的作用，尽管细胞之间相互移动的机制尚不清楚。我们在一个简单的、实验上容易处理的模型斑马鱼中研究了这些机制。通过我们的工作，我们将了解控制细胞运动的基本细胞属性和机制，这些很可能在整个动物发育过程中被广泛使用。这一知识最终可能有助于理解发育过程中细胞运动异常导致的疾病状态，甚至是那些发生在生命后期的疾病状态，如转移性癌症。