Intrinsic and extrinsic mechanisms regulating asymmetric cell division in C. elegans

调节线虫不对称细胞分裂的内在和外在机制

• 批准号: RGPIN-2016-03979
• 负责人: Hawkins, Nancy
• 金额: $ 2.26万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629050
• 关键词: Intrinsic; extrinsic; mechanisms; regulating; asymmetric

Asymmetric cell division, the process by which a mother cell divides to produce two daughter cells that adopt distinct cell fates, is a key mechanism that generates cellular diversity during development. Both the asymmetric localization of intracellular proteins and cell signaling contribute to this process. Despite numerous studies many outstanding questions remain. How does cell signaling polarize asymmetrically dividing cells? How does an organism integrate cell signaling to regulate the asymmetric localization of intracellular determinants.

不对称细胞分裂，即母细胞分裂产生两个具有不同细胞命运的子细胞的过程，是在发育过程中产生细胞多样性的关键机制。细胞内蛋白质的不对称定位和细胞信号传导都有助于这一过程。尽管进行了大量研究，但仍存在许多悬而未决的问题。细胞信号是如何阻止细胞不对称分裂的？生物体如何整合细胞信号以调节胞内决定簇的不对称定位。