Coordination of metabolic and signal transduction pathways

代谢和信号转导途径的协调

• 批准号: RGPIN-2016-06339
• 负责人: MacNeil, Lesley
• 金额: $ 3.13万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629052
• 关键词: Coordination; metabolic; signal; transduction; pathways

During development cells divide, differentiate, and organize themselves into specialized tissues and organs. These processes require cellular building blocks that are produced by metabolic pathways using precursors supplied in the diet. When nutrients are lacking, or when there is metabolic dysfunction, cells must adapt to optimize the use of nutrients, prioritize certain cellular functions and adjust others to cope with the availability of critical metabolites. For these reasons, cells must convey metabolic information to the cellular signaling pathways that regulate growth and development. The mechanisms involved in conveying this information are not completely understood.

在发育过程中，细胞分裂、分化并组织成专门的组织和器官。这些过程需要通过代谢途径使用饮食中提供的前体产生的细胞构建块。当营养素缺乏时，或者当存在代谢功能障碍时，细胞必须适应以优化营养素的使用，优先考虑某些细胞功能，并调整其他功能以科普关键代谢物的可用性。由于这些原因，细胞必须将代谢信息传递给调节生长和发育的细胞信号传导途径。传递这一信息的机制尚未完全了解。