Spatial and temporal control of meiosis

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Egg activation is the process by which a mature egg is triggered to complete meiosis and at the same time to undergo critical developmental changes that prepare the egg for subsequent embryonic development. The cort gene, which encodes a meiosis-specific activator of the Anaphase Promoting Complex (APC/C), is involved in almost all aspects of egg activation. A small number of other genes have also been implicated in egg activation, including the CanB2 phosphatase and CycB3-Cdk1. A major goal of our research is to determine how these genes interact to promote the completion of meiosis. We are also interested in discovering how these cell cycle regulators also control critical developmental processes that are linked to egg activation.