Spatial and temporal control of meiosis

减数分裂的空间和时间控制

• 批准号: RGPIN-2017-05839
• 负责人: Swan, Andrew
• 金额: $ 2.48万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629068
• 关键词: Spatial; temporal; control; meiosis

Egg activation is the process by which a mature egg is triggered to complete meiosis and at the same time to undergo critical developmental changes that prepare the egg for subsequent embryonic development. The cort gene, which encodes a meiosis-specific activator of the Anaphase Promoting Complex (APC/C), is involved in almost all aspects of egg activation. A small number of other genes have also been implicated in egg activation, including the CanB2 phosphatase and CycB3-Cdk1. A major goal of our research is to determine how these genes interact to promote the completion of meiosis. We are also interested in discovering how these cell cycle regulators also control critical developmental processes that are linked to egg activation.

卵子激活是触发成熟卵子完成减数分裂的过程，同时经历关键的发育变化，为卵子随后的胚胎发育做好准备。 cort 基因编码减数分裂特异性后期促进复合体 (APC/C) 激活剂，几乎参与卵子激活的所有方面。少数其他基因也与卵子激活有关，包括 CanB2 磷酸酶和 CycB3-Cdk1。我们研究的一个主要目标是确定这些基因如何相互作用以促进减数分裂的完成。我们还有兴趣发现这些细胞周期调节剂如何控制与卵子激活相关的关键发育过程。