Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models

使用 iPSC 衍生的心肌细胞和斑马鱼全心作为转化模型研究遗传性和获得性长 QT 综合征的药物治疗

• 批准号: 372315
• 负责人: Claydon Thomas W
• 金额: $ 49.6万
• 依托单位: Simon Fraser University (Burnaby, B.C.)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=372315&lang=en
• 关键词: Activator Drugs; Crispr Genome Editing; Electrophysiology; Herg Potassium Channel; Induced Pluripotent Stem Cells; Long Qt Syndrome

Each heart beat is generated by a co-ordinated wave of electrical excitation that spreads across the heart muscle. Each wave causes the muscle to contract and pump blood in the circulation. The waves have to be tightly controlled so that the heart beats i

每一次心跳都是由分布在心肌上的协调的电兴奋波产生的。每一波都使肌肉收缩并在循环中泵血。必须严格控制这些波，使心脏跳动，