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Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models

Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models
使用 iPSC 衍生的心肌细胞和斑马鱼全心作为转化模型研究遗传性和获得性长 QT 综合征的药物治疗
批准号：
372315
负责人：
Claydon Thomas W
金额：
$49.6万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=372315&lang=en
关键词：
Activator Drugs Crispr Genome Editing Electrophysiology Herg Potassium Channel Induced Pluripotent Stem Cells Long Qt Syndrome

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中文摘要
翻译
每一次心跳都是由分布在心肌上的协调的电兴奋波产生的。每一波都使肌肉收缩并在循环中泵血。必须严格控制这些波，使心脏跳动，
英文摘要
Each heart beat is generated by a co-ordinated wave of electrical excitation that spreads across the heart muscle. Each wave causes the muscle to contract and pump blood in the circulation. The waves have to be tightly controlled so that the heart beats i
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Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
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