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Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs

Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
基于机制的 hiPSC-CM 中 hERG 通道功能障碍的靶向挽救
批准号：
489300
负责人：
Claydon Thomas W
金额：
$65.2万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=489300&lang=en
关键词：
Activator Drugs Cell Patterning Crispr-Cas9 Electrophysiology Herg Potassium Channels Human Induced Pluripotent Cells Long Qt Syndrome Mathematical Modeling Multi-Electrode Array Optical Mapping

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Each heart beat is generated by a co-ordinated wave of electrical excitation that spreads across the heart muscle. Each wave causes the muscle to contract and pump blood in the circulation. The waves have to be tightly controlled so that the heart beats i
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Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models
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