课题基金 / 基金详情

Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs

Mechanism-based targeted rescue of hERG channel dysfunction in hiPSC-CMs
基于机制的 hiPSC-CM 中 hERG 通道功能障碍的靶向挽救
批准号：
489300
负责人：
Claydon Thomas W
金额：
$65.2万
依托单位：
Simon Fraser University (Burnaby, B.C.)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=489300&lang=en
关键词：
Activator Drugs Cell Patterning Crispr-Cas9 Electrophysiology Herg Potassium Channels Human Induced Pluripotent Cells Long Qt Syndrome Mathematical Modeling Multi-Electrode Array Optical Mapping

项目摘要

项目成果

Claydon Thomas W的其他基金

相似基金

相关文献

中文摘要
翻译
每一次心跳都是由在心肌中传播的协调的电激发波产生的。每一波都会引起肌肉收缩，将血液泵入循环系统。电波必须被严格控制，这样心脏才能跳动
英文摘要
Each heart beat is generated by a co-ordinated wave of electrical excitation that spreads across the heart muscle. Each wave causes the muscle to contract and pump blood in the circulation. The waves have to be tightly controlled so that the heart beats i
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Investigating drug therapies for inherited and acquired long QT syndrome using iPSC-derived cardiomyocytes and zebrafish whole hearts as translational models
海外基金