Mitochondrial dynamics: regulation mechanisms and physiologic impact.

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The morphological state of mitochondria has been linked to energy production, cell health and apoptosis. Mitochondrial shape is widely ascribed to a balance between mitochondrial fission and fusion. However it is underappreciated that they are morphologically pliable organelles that change their shape without undergoing fission. They exhibit reversible "rounding", which results in shorter organelles, a process we refer to as remodelling. We will explore the regulatory mechanisms and functional significance of mitochondrial remodelling in astrocytes. The central thesis is that mitochondrial remodelling is a critical process in the regulation of mitochondrial morphology and therefore cellular homeostasis.