Mitochondrial dynamics: regulation mechanisms and physiologic impact.

线粒体动力学：调节机制和生理影响。

• 批准号: RGPIN-2017-06498
• 负责人: Rintoul, Gordon
• 金额: $ 1.89万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629162
• 关键词: Mitochondrial; dynamics; regulation; mechanisms; physiologic

The morphological state of mitochondria has been linked to energy production, cell health and apoptosis. Mitochondrial shape is widely ascribed to a balance between mitochondrial fission and fusion. However it is underappreciated that they are morphologically pliable organelles that change their shape without undergoing fission. They exhibit reversible "rounding", which results in shorter organelles, a process we refer to as remodelling. We will explore the regulatory mechanisms and functional significance of mitochondrial remodelling in astrocytes. The central thesis is that mitochondrial remodelling is a critical process in the regulation of mitochondrial morphology and therefore cellular homeostasis.

线粒体的形态状态与能量产生、细胞健康和凋亡有关。线粒体的形状被广泛归因于线粒体分裂和融合之间的平衡。然而，人们低估了它们是形态学上柔韧的细胞器，可以在不发生分裂的情况下改变它们的形状。它们表现出可逆的“变圆”，这导致细胞器变短，我们称之为重塑的过程。我们将探讨星形胶质细胞线粒体重塑的调控机制和功能意义。中心论点是线粒体重塑是调节线粒体形态和细胞稳态的关键过程。