Dynamic Regulation of the Cell Surface Proteome

细胞表面蛋白质组的动态调控

• 批准号: RGPIN-2016-04371
• 负责人: Antonescu, Costin
• 金额: $ 2.26万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629191
• 关键词: Dynamic; Regulation; Cell; Surface; Proteome

Each living cell must interact with its surroundings through the molecules present on its outer surface. Proteins are an important type of molecule found on every cell’s surface. These cell surface proteins are essential for many cellular functions including the uptake of nutrients such as sugar and vitamins from a cell's surroundings, for attachment to other cells or tissues and for sensing messages from other cells or organisms (e.g. through hormones). The proteins found on a cell’s surface work as part of cellular processes that can require a lot of a cell’s energy resources, for example in cell movement or migration. Much like household income and expenditures should be balanced, a cell’s energetically demanding processes have to be tightly controlled so that energy expenditure is kept in line with a cell’s needs and abilities.

每个活细胞都必须通过其外表面的分子与周围环境相互作用。蛋白质是在每个细胞表面发现的一种重要分子。这些细胞表面蛋白质对于许多细胞功能是必需的，包括从细胞周围摄取营养物如糖和维生素，用于附着到其他细胞或组织以及用于感测来自其他细胞或生物体的信息（例如通过激素）。在细胞表面发现的蛋白质作为细胞过程的一部分工作，可能需要大量的细胞能量资源，例如在细胞运动或迁移中。就像家庭收入和支出应该平衡一样，细胞的能量需求过程必须严格控制，以便能量支出与细胞的需求和能力保持一致。