Dynamic Regulation of the Cell Surface Proteome

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Each living cell must interact with its surroundings through the molecules present on its outer surface. Proteins are an important type of molecule found on every cell’s surface. These cell surface proteins are essential for many cellular functions including the uptake of nutrients such as sugar and vitamins from a cell's surroundings, for attachment to other cells or tissues and for sensing messages from other cells or organisms (e.g. through hormones). The proteins found on a cell’s surface work as part of cellular processes that can require a lot of a cell’s energy resources, for example in cell movement or migration. Much like household income and expenditures should be balanced, a cell’s energetically demanding processes have to be tightly controlled so that energy expenditure is kept in line with a cell’s needs and abilities.